Diagnostic liposomal compositions for enhancing NMR imaging

Details Diagnostic liposomal compositions for enhancing NMR imaging Diagnostic liposomal compositions for enhancing NMR imaging

1993-11-12

1995-04-18

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436173, 424450, 514492, 514502, 514836, A61B 5055, A61K 3722

Patent

active

054076609

ABSTRACT:
Nuclear magnetic resonance (NMR) imaging of body organs and tissues is enhanced by administering to a living animal body a diagnostic composition comprising a diagnostically effective amount of a substantially nontoxic paramagnetic image altering agent containing a chelate of a paramagnetic element such as magnesium, gadolinium or iron, carried by a liposome. The chelate is carried by or within or outside the external surface of the liposome in such a manner that after arrival at or delivery to the desired organ or tissue site, the paramagnetic image altering agent is released in a diagnostically useful fashion.

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Guilmette, R. A. et al. Life Sciences 22(4):313-320 (1978).
Perrin, D. D. et al. Pharmacol. Ther. 12:255-297 (1981).
Pulsieux, F. et al. Biomed. Pharmacother. 36:4-13 (1982).
Ryman, B. et al. Proc. Feb. Mett. 56(Mol. Dis.):79-88 (1978).

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