Diagnostic histopathology using multiplex gene expression FISH

Details Diagnostic histopathology using multiplex gene expression FISH Diagnostic histopathology using multiplex gene expression FISH

2006-04-14

2011-11-22

Sisson, Bradley L (Department: 1634)

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Hetero-o

C436S800000, C536S023100, C536S024300

Reexamination Certificate

active

08062897

ABSTRACT:
The present invention relates to a method for detecting one or more nascent RNAs in a tissue sample using FISH. In the method, a plurality of probes (8 to 82) may be used to detect a single species of nascent RNA. Further, a plurality of nascent RNA species may be detected simultaneously using between 8 and 82 probes for each nascent RNA. The invention comprises, in addition, methods of preparing a sample for nascent RNA detection by reducing autofluorescence of the tissue sample. These techniques may be synergistically combined to achieve significantly improved results.

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