Diagnostic for Sjogren's syndrome

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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53038824, 530868, C07K 1618

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active

058958126

ABSTRACT:
The present invention relates to a novel polypeptide which has secretion enhancing activity on lacrimal and parotid gland cells, monoclonal antibodies thereto, and methods of diagnosising Sjorgren's syndrome using these antibodies.

REFERENCES:
H.J. Ellis et al, GUT, 33, 1504-1507, 1992.
G.W. Laurie et al, Invest. Opthamol. & Visual Science, 35, 1825, 1994.
G.W. Laurie et al, Biochem. Biophys. Research Communic. 217, 10-15, 1995.
E. Harlow et al, Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, 1988, pp. 61-71.
J.W. Goding, Monoclonal Antibodies: Principles and Practice, Academic Press, 1986, pp. 282-286.
E. Harlow et al, Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, 1988, pp. 23-28.

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