Surgery – Miscellaneous – Methods
Patent
1997-03-21
1999-09-07
Yu, Mickey
Surgery
Miscellaneous
Methods
600368, A61B 1900
Patent
active
059471247
ABSTRACT:
The present invention relates to methods for determining the time of a myocardial infarction in a patient by measuring the ratio of oxidized to reduced troponin I in a blood sample obtained from the patient. This ratio is measured through the use of two or more distinct components which specifically bind oxidized troponin I, reduced troponin I, and/or both forms of troponin I present in the blood sample. Each distinct component may be an antibody or an antibody fragment. The measured ratio reflects the time elapsed from the time of the myocardial infarction.
REFERENCES:
patent: 5560937 (1996-10-01), Lee et al.
patent: 5583200 (1996-12-01), Larue et al.
patent: 5756682 (1998-05-01), Wicks et al.
Martins et al. "Comparison of Cardiac Troponin I and Lactate Dehydrogenase Isoenzymes for the Late Diagnosis of Myocardial Injury" Am J Clin Pathol 106:705-8, Dec. 1996.
Tucker et al. "Early Diagnostic Efficiency of Cardiac Troponin I and Troponin I for Acute Myocardial Infarction" Acad Emerg Med 4(1):13-21, Jan. 1997.
Brogan et al. "Evaluation of a New Assay for Cardiac Troponin I Vs. Creatine Kinase-MB for the Diagnosis of Acute Myocardial Infarction" Acad Emerg Med 4(1): 6-12, Jan. 1997.
Buechler Kenneth Francis
McPherson Paul H.
Biosite Diagnostics Incorporated
O'Hara Kelly
Yu Mickey
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