Diagnostic device incorporating a biochemical ligand

Details Diagnostic device incorporating a biochemical ligand Diagnostic device incorporating a biochemical ligand

1984-05-25

1985-12-31

Marantz, Sidney

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

324 711, 435 14, 435176, 436526, 436527, 436806, C12M 134, G01N 3354

Patent

active

045621578

ABSTRACT:
A device useful in diagnostics in which a biochemical species is attached to the surface of a sensor, especially to the gate of a field effect transistor. In such a "BIOCHEMFET" it has been a problem to attach two or more biochemical species to the surface of the sensor, especially to the gates of a multi-gated FET. It has now been found possible to bond a group having a photoactivatable function covalently to the sensor surface, photo-expose the resultant modified surface selectively, e.g. through a mask, and bond the biochemical species, e.g. a hapten, antigen, antibody, lectin or enzyme, to the photoactivated function. In this way the biochemical species becomes attached in selected areas only. In view of the success of this technique realized under conditions of miniaturization, the invention makes possible "printed circuits for proteins".
In addition to the device are the process of manufacture thereto, use for diagnostic purposes and a diagnostic kit of the device and a partner capable of binding to the biochemical species.

REFERENCES:
patent: 4072576 (1978-02-01), Arwin
patent: 4238757 (1980-12-01), Schenck
patent: 4314821 (1982-02-01), Rice
patent: 4444878 (1984-04-01), Paulus
patent: 4444892 (1984-04-01), Malmros
Chemical Abstracts, 93:88076h (1980).
Breslow, R. et al., J.A.C.S., 96, 5937-5939 (Sep. 4, 1974).

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