Diagnostic device for visually detecting presence of biological

Details Diagnostic device for visually detecting presence of biological Diagnostic device for visually detecting presence of biological

1975-05-27

1976-09-07

Wolk, Morris O.

Chemistry: physical processes

Physical processes

Crystallization

23230B, 128 2R, 204192, 424 12, 427250, 428336, 428434, 428469, 428474, G01N 3316

Patent

active

039791840

ABSTRACT:
Devices for the detection of biological particles, particularly proteins. Such devices comprise a non-transparent surface of metal (solid metal or a non-transparent coating of metal on some different substrate) covered with a thin transparent first layer of dielectric material, which in turn has a transparent second layer of metal adhered over the outer surface thereof, the transparent layer preferably being in the form of metal globules or metal islets. The detection device as provided to the user will usually have a monomolecular layer of biological particles applied over at least a portion of the transparent layer of metal. Interference of light is obtained useful in distinguishing between monomolecular layers and multi-molecular layers with the unaided eye, when the non-transparent surface metal reflects light relatively poorly and is at least approximately matched to the light reflecting ability of the dielectric material forming the transparent layer thereover.

REFERENCES:
patent: 3271179 (1966-09-01), Smith, Jr.
patent: 3530055 (1970-09-01), Maissel
patent: 3691045 (1972-09-01), Lieberman
patent: 3853467 (1974-12-01), Giaever
M. Francon, "Modern Applications of Physical Optics," pp. 19-21, Interscience, New York, 1963.

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