Diagnostic composition containing an LH-RH antagonist for hyster

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing

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424 95, 530313, 530328, 514 15, 514800, 930130, A61K 4900, A61K 3804, A61K 3800, G01N 100

Patent

active

061068055

ABSTRACT:
The invention relates to a diagnostic composition for improving the effectiveness of hysteroscopy, characterized in that it contains an LH-RH antagonist, in particular cetrorelix. The composition is envisaged for use prior to hysteroscopy and/or for preparation for surgery, specifically in a single dose of between 0.1 and 2 mg/kg.
However, the composition can also be administered, for use prior to hysteroscopy and/or for preparation for surgery, in a multiple dose of between 0.01 and 0.5 mg/kg, preferably spread over 1-14 days. The composition is furthermore suitable for use in hysteroscopy in combination with the subsequent treatment of pathological conditions of the uterus such as myoma and endometrial hyperplasia.

REFERENCES:
patent: 4800191 (1989-01-01), Schally et al.
patent: 5198533 (1993-03-01), Schally et al.
patent: 5574011 (1996-11-01), Tien
patent: 5663145 (1997-09-01), Engel et al.
Ph. Merviel, J. L. Mergui, J. Salat-Baroux, Operative-Hysteroscopy in 1995. Equipment, technique, indications and results. Contracept. Fertil. Sex.--1995--vol. 23, n 9, pp. 516-523.
L. Boubli, B. Blanc, B. Barry, E. Bautrant, Treatment by LHRH agonist before Hysteroscopic resection of myoma, Contracept. Fertil. Sex.--1992--vol. 20, n 5, pp. 567-570.

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