Diagnostic blood test to identify infants at risk for sepsis

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435973, 436519, 436800, 436811, G01N 3353

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active

058306790

ABSTRACT:
Disclosed is a method of diagnosing sepsis in a human infant. The method includes detecting an increase in the expression of leukocyte cell surface antigens in a blood sample from an infant at risk for developing sepsis.

REFERENCES:
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Berry et al., "Premature Parturition is Characterized by In Utero Activation of the Fetal Immune System", Amer. J. of Obstetrics and Gynecology 173:1315-1320, 1995.
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DeLogu et al., "Serum Neopterin and Soluble Interlukin-2 Receptor for Prediction of a Shock State in Gram-Negative Sepsis", J. of Critical Care 10:64-71, 1995.
Eichacker et al., "Leukocyte CD11b/18 Antigen-Directed Monoclonal Antibody Improves Early Survival and Decreases Hypoxemia . . . Challenged with Tumor Necrosis Factor", Amer. Rev. Res. Disease 145:1023-1029, 1992.
Ridings et al., "A Dual-Binding Antibody to E-and L-Selectin Attenuates Sepsis-Induced Lung Injury", Respiratory and Critical Care Medicine 152:247-253, 1995.
Spear et al., "Soluble Interleukin-2 Receptor As A Predictor of Neonatal Sepsis", J. of Pediatrics 126:982-985, 1995.
Cecoon et al., "Immunological Markers in Neonates With Risk Factors for Early Sepsis at Different Gestational Ages," Pediatric Research, 39 (4 Part 2), p. 287A, Abstract No. 1705, Apr. 1996.
Weinschenk et al., "Activation of Leukocyte Cell Surface Markers in Neonatal Sepsis." Pediatric Research, 39 (4 Part 2), p. 292A Abstract No. 1739, Apr. 1996.
Weirich et al., "CD11b Expression on Granulocytes as a Diagnostic Marker for Neonatal Sepsis." Pediatric Research, 39 (4 Part 2), p. 303A, Abstract No. 1805, Apr. 1996.

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