Diagnostic assay system

Details Diagnostic assay system Diagnostic assay system

1989-07-11

1994-11-15

Parr, Margaret

Chemistry: analytical and immunological testing

Thyroid hormone tests

436501, 436512, 436546, 436805, 422 56, G01N 3353, G01N 33563, G01N 33533, G01N 2100

Patent

active

053647963

ABSTRACT:
There is described an assay system for the assessment of unoccupied specific ligand binding sites on proteins in biological fluids. The assay is carried out with a multilayer assay element and is based on the principle of equilibrium distribution in which a ligand distributes itself between unoccupied sites on the proteins and the remainder of the element. The ligand can be labeled with a detectable moiety or it may be unlabeled and detected through the use of another detectable species. In one embodiment the assay format is utilized to estimate the number of sites on thyroxine binding globulin (TBG) which are not occupied by thyroxine (T4) or triiodothyronine (T3).

REFERENCES:
patent: 3941564 (1976-03-01), Fader et al.
patent: 4252782 (1981-02-01), Bailey
patent: 4381291 (1983-04-01), Ekins
patent: 4824777 (1989-04-01), Chang et al.
patent: 4900686 (1990-02-01), Arnost et al.
patent: 4906439 (1990-03-01), Grenner

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