Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-03-14
2006-03-14
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S013000, C436S518000, C514S054000, C514S056000, C536S021000
Reexamination Certificate
active
07011953
ABSTRACT:
Methods for detecting the presence of antibodies to PF4/heparin/TSP-1 complexes in a biological sample and for diagnosing Type 2 heparin-induced thrombocytopenia are described.
REFERENCES:
patent: 4281061 (1981-07-01), Zuk et al.
patent: 4444879 (1984-04-01), Foster et al.
patent: 5466582 (1995-11-01), Amiral
patent: 5585243 (1996-12-01), Aster et al.
patent: 5763201 (1998-06-01), Tomer
patent: 6312694 (2001-11-01), Thorpe et al.
patent: WO 97/32211 (1997-09-01), None
Guo et al, Heparin-binding Peptides from the Type I Repeats of Thrombospondin, 1992, The Journal of Biological Chemistry, vol. 267, No. 27, Issue of Sep. 25, pp. 19349-19355.
Gogstad et al, British Journal of Haematology (England) Apr. 1983, vol. 53, No. 4, pp. 563-573 (Abstract Provided).
Amiral, J., et al., “Antibodies to Macromolecular Platelet Factor 4-Heparin Complexes in Heparin-Induced Thrombocytopenia: a Study of 44 Cases,”Thrombosis and Haemostasis, 73(1):21-28, (1995).
Amiral, J., et al., “Pathogenicity of IgA And/or IgM Antibodies to Heparin-PF4 Complexes in Patients with Heparin-Induced Thrombocytopenia,”British Journal of Haematology, 92:954-959, (1996).
Amiral, J., et al., “Generation of Antibodies to Heparin-PF4 Complexes Without Thrombocytopenia in Patients Treated With Unfractionated or Low-Molecular-Weight Heparin,”American Journal of Hematology, 52:90-95, (1996).
Griffiths, E. and Dzik, W.H., “Assays for Heparin-Induced Thrombocytopenia,”Transfusion Medicine, 7:1-11, (1997).
Horne, M.K. III, and Hutchison K.J., “Simultaneous Binding of Heparin and Platelet Factor-4 to Platelets: Further Insights Into the Mechanism of Heparin-Induced Thrombocytopenia,”American Journal of Hematology, 58:24-30, (1998).
Newman P.M., et al., “Heparin-Induced Thrombocytopenia: IgC Binding to PF4-Heparin Complexes in the Fluid Phase and Cross-Reactivity with Low Molecular Weight Heparin and Heparinoid,”Thromb Haemost. 82:157-158, (1999).
Suh J.S., et al., “Antibodies from Patients with Heparin-Induced Thrombocytopenia/Thrombosis Recognize Different Epitopes on Heparin: Platelet Factor 4,”Blood91(3): 916-922, (1998).
Stringer, S.E. and Gallagher, J.T., “Specific Binding of the Chemokine Platelet Factor 4 to Heparan Sulfate,”The Journal of Biological Chemistry, 272(33):20508-20514, (1997).
Visentin G.P., et al., “Antibodies from Patients with Heparin-Induced Thrombocytopenia/Thrombosis Are Specific for Platelet Factor 4 Complexed with Heparin or Bound to Endothelial Cells,”J. Clin. Invest. 93:81-88, (1994).
Warkentin, T.E., et al., “Heparin-Induced Thrombocytopenia: Towards Consensus,”Thrombosis and Haemostasis, 79:1-7, (1998).
Abdelouahed Mustapha
Lawler John W.
Davis Deborah A.
Hamilton Brook Smith & Reynolds P.C.
Le Long V.
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