Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2002-09-10
2008-05-06
Gabel, Gailene Rio (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S006120, C435S007920, C435S007940, C436S016000, C436S501000, C436S517000, C436S548000, C436S811000, C436S819000, C530S359000
Reexamination Certificate
active
07368247
ABSTRACT:
Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for TSEs, especially CJD. The invention provides a diagnostic assay for either of these markers, preferably by enzyme immunoassay using a specific antibody thereto. Since H-FABP is also a marker for acute myocardial infarction (AMI), to distinguish CJD from AMI requires an assay specific to AMI, e.g. using troponin-1 or CK-MB as a marker, also to be carried out.
REFERENCES:
patent: 0 861 900 (1998-09-01), None
patent: 2 763 692 (1998-11-01), None
patent: WO 98/23962 (1998-06-01), None
patent: WO 98/45440 (1998-10-01), None
patent: WO 99/04237 (1999-01-01), None
Strongin, Sensitivity, Specificity, and Predictive Value of Diagnostic Tests: Definitions and Clinical Applications, Laboratory Diagnosis of Viral Infections, Lennette, E., ed., Marcel Dekker Inc., New York, pp. 211-219 (1993).
Pu et al. “Expression of fatty acid binding proteins is altered in aged mouse brain,” Mol Cell Biochem, 1999, 198:69-78.
Ohkaru et al., “Development of a sandwich enzyme-linked immunosorbent assay for the determination of human heart type fatty acid-binding protein in plasma and urine by using two different monoclonal antibodies specific for human heart fatty acid-binding protein,” 1995, Journal of Immunological Methods, 178:99-111.
Meyers-Payne et al. “Isolation and Characterization of Two Fatty Acid Binding Proteins from Mouse Brain”, Journal of Neurochemistry, 1996, 1648-1656.
Gorski et al., Increased Fatty Acid-Binding Protein Concentration In Plasma of Patients with Chronic Renal Failure, Depts. of Physiol and Nephrol, 193-195.
Myers-Payne, S., et al., Isolation and Characterization of Two Fatty Acid Binding Proteins from Mouse Brain, 1996, ,Journal of Neurochemistry, 1648-1656.
Godbout, R. et al., Correlation of B-FABP and GFAP Expression in Malignant Glioma, 1998,Oncogene, 1955-1962.
Kurtz, A. et al., The Expression Pattern of a Novel Gene Encoding Brain-fatty Acit Binding Protein Correlates With Neuronal and Glial Cell Development, 1994,The Company of Biologists Limited, 2637-2649.
Guillaume Elisabeth
Hochstrasser Denis Francois
Sanchez Jean-Charles
Zimmermann Catherine Gabrielle
Arent & Fox LLP
Gabel Gailene Rio
Universite De Geneve
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