Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2007-09-11
2007-09-11
Mosher, Mary E. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S006120, C536S023720, C536S024320, C536S024330
Reexamination Certificate
active
10808187
ABSTRACT:
The present invention relates to a diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a real-time quantitative PCR assay for the detection of hSARS virus using reverse transcription and polymerase chain reaction. Specifically, the quantitative assay is a TaqMan® assay using the primers and probes constructed based on the genome of the hSARS virus. The invention further relates to a diagnostic kit that comprises nucleic acid molecules for the detection of the hSARS virus.
REFERENCES:
patent: 2001/0053519 (2001-12-01), Fodor et al.
patent: WO 2004/092383 (2004-10-01), None
Peiris et al (Lancet 361: 1319-1325, published online Apr. 8, 2003).
Drosten et al (New England Journal of Medicine 348:1967-1976, published online Apr. 10, 2003).
Ksiazek et al (New England Journal of Medicine 348:1953-1966, published online Apr. 10, 2003).
Genbank Accession No. AY274119, “SARS Coronavirus Tor2, complete genome,” version AY274119.1, Apr. 14, 2003.
SARS-associated Coronavirus. Genomic Sequence Availability. [online][retreived on Jul. 21, 2005]. Retrieved from the Internet <URL: http://www.bcgsc.ca/bioinfo/SARS>.
Chan Kwok Hung
Guan Yi
Nicholls John M.
Peiris Joseph S. M.
Poon Lit Man
Dickstein , Shapiro, LLP.
Mosher Mary E.
The University of Hong Kong
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