Diagnostic assay for stroke

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007400, C435S007920, C435S287200, C435S970000, C435S973000, C436S501000, C436S514000, C436S517000, C436S528000, C436S530000, C436S548000, C436S013000, C436S015000, C436S016000, C436S071000, C436S811000

Reexamination Certificate

active

07144705

ABSTRACT:
Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using anti-H-FABP or B-FABP antibody. Since H-FABP is also a marker for acute myocardial infarction (AMI), to distinguish stroke from AMI requires an assay specific to AMI, e.g. using troponin-I or creatine kinase-MB as a marker, also to be carried out.

REFERENCES:
patent: 5710008 (1998-01-01), Jackowski
patent: 0962878 (1999-12-01), None
patent: 9735878 (1997-10-01), None
patent: 9845440 (1998-10-01), None
patent: WO 98/45440 (1998-10-01), None
patent: 9857171 (1998-12-01), None
Fujii et al., Increased Renal FABP in spontaneously hypertensive rats, Journal of Hypertension 6: 671-675 (1988).
Ishii et al., Serum concentration of myoglobin vs human heart type FABP in early detection of acute myocardial infarction, Clinical Chemistry 43 (8): 1372-1378 (1997).
Nieuwenhoven et al. “Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid binding protein,” 1995, Circulation 92:2848-2854.
Gorski et al. “Increased fatty acid binding protein concentration in plasma of patients with chronic renal failure,” 1997, Clinical Chemistry, 43:193-195.
Takahashi et al. “Rapid and sensitive immunoassay for the measurement of serum S100B using isoform specific monclonal antibody,” 1999, Clinical Chemistry, 45:1307-1311.
Shimizu et al. “Isolation and expression of a cDNA for a human brain fatty acid binding protein (B-FABP),” 1997, Biochimica et Biophysica Acta 1354:24-28.
Fujii et al., “Increased renal fatty acid binding protein in spontaneously hypertensive rats,” Journal of Hypertension. 1988, 6:671-675.
Fujii et al., “Fatty acid binding protein in kidney of normotensive and genetically hypertensive rats,” Hypertension. 1987, 10:93-99.
Glossary of Terms from the National Stroke Association website, www.stroke.org, printed Aug. 11, 2001, pp. 1-7 as printed.
L. Pu et al., “Expression of fatty acid binding proteins is alteredin aged mouse brain”, Molecular and Cellular Biochemistry 1999; 198:69-78.
M. Takahashi et al., “Rapid and sensitive immunoassay for the measurement of serum S100B using isoform-specific monoclonal antibody”, Clin. Chem. 1999;45:1307-11.
M. Robers et al., “Development of a rapid microparticle-enhanced turbidimetric immunoassay for plasma fatty acid-binding protein, an early marker of acute myocardial infarction”, Clin. Chem. 1998; 44:1564-1567.
A. Schreiber et al., 1998, “Recombinant human heart-type fatty acid binding protein as standard in immunochemical assays”, Clin Chem Lab Med 1998; 36: 283-288.
U. Missler et al., “S100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemia stroke”, Stroke 1997;28:1956-.
F. Shimizu et al., “Isolation and expression of a cDNA for human brain fatty acid binding protein (B-FABP)”, Biochim. Biophys. Acta 1997;1354:24-28.
J. Ishii et al., “Serum concentrations of myoglobin vs. human heart-type cytoplasmic fatty-acid binding protein in early detection of acute myocardial infarction”, Clinical Chemistry 1997;43 1372-1378.
W. Roos et al., “Monoclonal antibodies to human heart type fatty acid-binding protein”, J. Immunol. Methods 1995;183 149-153.
E. R. Hendrickson et al., “High sensitivity multianalyte immunoassay using covalent DNA-labeled antibodies and polymerase chain reaction”, Nucleic Acids Research 1995; 23, 522-529.
T. Sano et al., “Immuno-PCR” ed. Robert A. Meyers, VCH Publishers, Inc. (1995), pp. 458-460.
P. A. Sellner et al., “Development role of fatty acid binding proteins in mouse brain” Dev. Brain Res. 1995;89:33-46.
J. M. Murphy et al., “Performance of screening and diagnostic tests”, Arch. Gen. Psychiatry 1987;44:550-555.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Diagnostic assay for stroke does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diagnostic assay for stroke, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnostic assay for stroke will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3699601

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.