Diagnostic assay for breast cancer in human female patients

Details Diagnostic assay for breast cancer in human female patients Diagnostic assay for breast cancer in human female patients

1991-08-23

1992-07-14

Warden, Robert J.

Chemistry: analytical and immunological testing

Cancer

436 63, 436813, 436169, 422 70, 210635, 210656, G01N 3348

Patent

active

051302560

ABSTRACT:
A method for determining whether a woman with gross cystic disease will develop breast cancer is provided. The method comprises analyzing human breast cyst fluid for the presence of a unique factor which has a retention time on an Amino Carbohydrate HPLC column of between about 6.4 minutes and about 6.7 minutes. The presence of this factor is diagnostically predictive for breast cancer.

REFERENCES:
patent: 4440863 (1984-04-01), Haagensen
Raju et al., "Correlation of Concentrations of Estriol-3-Sulfate With Those of Potassium and Sodium in Human Breast Cyst Fluid", Steroids 45(3-4) pp. 341-346 (1985).
Raju et al., "Estriol Conjugates in Human Breast Cyst Fluid and in Serum of Premenopausal Women", J. of Clin. Endocrinol. Metab. (45)(3) pp. 429-434 (1977).
Raju et al., "Estriol In Human Breast Cyst Fluid", J. Steroid Biochem. vol. 20, No. 4B pp. 1061-1065 (1984).
Raju et al. "Androsterone Long Chain Fatty Acid Esters in Human Breast Cyst Fluid", J. Clin. Endocrinol Metab. 60 No. 5 pp. 940-946 (1985).

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