Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1993-03-08
1995-07-18
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, C12Q 168, G01N 3353
Patent
active
054340462
ABSTRACT:
This invention relates to DNA encoding drug resistance to cis-platin. The invention also includes expression products of, and vectors and hosts comprising the DNA sequence encoding cis-platin resistance. Also included are immunodiagnostic assays of cis-platin resistance and assays for screening materials having a modulating effect on DNA encoding the cis-platin resistance gene and on the expression product thereof. The invention is further directed to antagonists to the cis-platin resistance gene and the expression product thereof. Recombinant and pharmaceutical means making use of the cis-platin resistance gene and its expression product are also provided.
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S. C. Pruitt, Expression vectors permitting cDNA cloning and enrichment for specific sequences by hybridization/selection Gene 66:121-134 (1988).
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R. E. Enns, Isolation of a gene associated with resistance to cisplatin Anti-Cancer Drug Des. 6:340 (1991).
R. E. Enns et al., Isolation and characterization of genes involved in low level cisplatin (DDP) resistance in human ovarian carcinoma cells Proc. Am. Assoc. Cancer Res. Ann. Meeting 30:420 (1989).
R. E. Enns et al., an amplified mitochondrial chaperonin gene causes resistance to cisplatin in human ovarian tumor cells Proc. Am. Assoc. Caner Res. 32:353 Abstract #2098 (1991).
H. Kimura et al., Regulation of the expression of heat shock protein 60 (HSP60) mRNA in a human ovarian carcinoma cell line Proc. am. Assoc. Caner Res. 33:362, Abstract #2161 (1992).
Enns Robert E.
Howell Stephen B.
Brunelle Jan P.
Carter Philip W.
Dreger Walter H.
Schwartz Richard A.
The Regents of the University of California
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