Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence
Reexamination Certificate
2006-10-23
2008-10-07
Blanchard, David J. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
11 to 14 amino acid residues in defined sequence
C530S326000
Reexamination Certificate
active
07432343
ABSTRACT:
The present invention provides nucleic acids. Polypeptides, antibodies and cells related to MAIL (Molecule possessing Ankyrin repeats Induced by LPS; or IκB-ζ), a novel member of the IκB family, expressed in LPS stimulated monocytes and uses thereof. The isolated nucleic acids, polypeptides, antibodies and cells of the invention can be used in detection assays, screening methods and drug discovery assays.
REFERENCES:
patent: 2005/0084916 (2005-04-01), Reinherz et al.
patent: WO 2005/102040 (2005-11-01), None
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Totzke Gudrun et al.: “A Novel Member of the I Kappa B Family, Human I Kappa B-zeta, Inhibits Transactivation of p65 and its DNA Binding” Journal of Biological Chemistry, vol. 281, No. 18, May 2006, pp. 12645-12654, XP002440291.
Yamazaki, Soh et al.: “Stimulus-Specific Induction of a Novel Nuclear Factor-kappaB Regulator, IkkapaB-zeta, via toll/interleukin-1 receptor is Mediated by MRNA Stabilization” Journal of Biological Chemistry, vol. 280, No. 2, Jan. 14, 2005, pp. 1678-1687 XP002440290.
Batheja Ameesha D.
D'Andrea Michael
Ho George
Uhlinger David J.
Blanchard David J.
Donnelly Laura
Gussow Anne M.
Janssen Pharmaceutica N.V.
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