Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-01-02
2007-01-02
Huff, Sheela J. (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S387300, C530S388850, C530S391300
Reexamination Certificate
active
09926323
ABSTRACT:
The invention concerns a method and a reagent kit for detecting cells in a biological sample using a double-fluorescence technique and the diagnostic and therapeutic application of amino acid sequence-specific antibodies against the urokinase receptor having a high affinity for tumour cell-expressed receptors.
REFERENCES:
patent: 5234816 (1993-08-01), Terstappen
patent: 5519120 (1996-05-01), Dano et al.
patent: 6638502 (2003-10-01), Li et al.
patent: 0317156 (1981-05-01), None
McHugh et al J immuno methods 1986 95:57-61, Abstract Only.
Fundamental Immunology 242 (William E. Paul, M.D. ed., 3d ed. 1993).
Rudikoff et al (Proc Natl Acad Sci USA vol. 79 p. 1979.
Tockman et al, Cancer Research vol. 52 p. 2711s (1992).
Janicke et al Fibrinolysis vol. 4 p. 69 (1990).
W. Xue et al.: Urokinase-type plasminogen activator receptors associate with betal and beta 3 integrins of fibrosarcoma cells: dependence on extracellular matrix components: Cancer Research vol. 57, No. 9, May 1, 1997, pp. 1682-1689, XP002117246 Baltimore, MD, VSA abstract; figure 1.
T. Luther et al.: “Epitope-mapped monocolonal antibodies as tools for functional and morphological analyses of the human urokinase receptor in tumor tissue” American Journal of Pathology, vol. 150 No. 4, Apr. 1997, pp. 1231-1244, XP002117251 Hagerstown, MD, VSA cited in the whole document.
R. Todd et al.: “CD87 Workshop Panel report (p. 1016-1020 in ‘Leucocyte Typing VI’, Eds. T. Kishimoto et al.)” 1997, Garland Publishing, Inc. XP002117252 Cited in the application figures tables.
V. Magdolen et al.: “Epitope-mapped monoclonal antibodies directed to the human urokinase receptor (uPAR, CD87),” Tissue Antigens, vol. 48, No. 4-2, Oct. 1996, p. 424 XP000929590 Kopenhagen, Dänemark Abstract MC-2-02.
K. Fischer et al.: “Urokinase induces proliferation of human ovarian cancer cells: characterization of strutural elements required for growth factor function.” Febs Letters, vol. 438, No. 1-2, Oct. 30, 1998, pp. 101-105, XP002143814 Amersterdam, die Niederland Abstract figure 3.
H. Allgayer et al.: “Immunocytochemical phenotyping of disseminated tumor cells in bone marrow by uPA and receptor and CK18: investigation of sensitivity and specificity of an immunogold/alkaline phosphatase double staining protocol” Journal of Histochemistry and Cytochemistry, vol. 45, no. 2, Feb. 1997, Baltimore, MD, USA cited in the application abstract.
M. Heiss et al.: “indivdual development and uPA-receptor expression of disseminated tumour cells in bone marrow: a reference to early systemic disease in solid cancer” Nature Medicine, vol. 1, No. 10, Oct. 1995, pp. 1035-1039, XP02117248 New York, NY, USA cited in the application p. 1039, column 1, line 18, paragraph 2—line 39.
I. Funke et al.: “comparative analyses of bone marrow micrometastases in breast and gastric cancer” International Journal of Cancer, vol. 65, No. 6, Mar. 15, 1996, pp. 755-761, XP002117249 New York, NY, USA cited in the application abstract.
R. Ciccocioppo et al.: “Detection of the receptor for the human urokinase-type flouresceinated uPA” Journal of Histochemistry and Cytochemistry, vol. 45, No. 9, Sep. 1997, Baltimore, MD, USA cited in the application figures 1, 2.
Graeff Henner
Harbeck Nadja
Noack Frank
Schmitt Manfred
Huff Sheela J.
Rothwell Figg Ernst & Manbeck P.C.
Wilex AG
LandOfFree
Diagnostic and therapeutic use of antibodies against the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diagnostic and therapeutic use of antibodies against the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnostic and therapeutic use of antibodies against the... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3774804