Diagnostic and therapeutic methods related to regulating...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C424S198100, C530S351000

Reexamination Certificate

active

07067472

ABSTRACT:
Compositions comprising OB-R agonists and methods of treatment for conditions such as systemic inflammatory response syndrome are provided. One suitable OB-R agonist ligand is recombinant human OB protein, also known as leptin. Also provided are methods and compositions for the treatment of obesity and OB resistance. Assay methods and kits relating to these conditions are also included.

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patent: WO 96/35787 (1996-11-01), None
Bennett, et al., A role for leptin and its cognate receptor in hematopoiesis, 1996,Current Biol., 6(9):1178-1180.
Gainsford, et al., Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells, 1996;Proc. Natl. Acad. Sci.,93:14564-14568.
Roubenoff, et al., TNF-alpha and leptin in adjuvant arthritis (AA): implications for inflammatory cachexia, 1996,Arthritis and Rheumatism, 39(9) supplement, Abstract No. 302, p. s77.
Sarraf, et al., Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia, 1997,J. Exper. Med.,185(1):171-175.

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