Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-12-17
2000-12-19
Nolan, Patrick
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 792, 435 29, 4353723, 530351, G01N 3353
Patent
active
061626090
ABSTRACT:
The present invention is directed to methods that can be used for diagnosing whether an individual either has, or is likely to develop, an autoimmune disease. The methods are based upon determining the level of CD4.sup.- CD8.sup.- V.alpha.24J.alpha.Q.sup.+ T cells present in the individual being tested or the pattern of cytokine secretion evidenced by these cells. In addition, the invention is directed to a therapeutic method for treating or preventing autoimmune disease which is based upon the specific expansion of the CD4.sup.- CD8.sup.- V.alpha.24J.alpha.Q.sup.+ T cell population.
REFERENCES:
The Murck Manual, 16.sup.th Ed, 1992, pp. 339-342.
Takayuki, et al., "Selective Reduction of T Cells Bearing Invariant V.alpha.24J.alpha.Q Antigen Receptor in Patients with Systemic Sclerosis," J.Exp. Med. 182:1163-1168 (1995).
International Search Report for PCT/US98/26868.
Abbas, et al., "Functional Diversity of Helper T Lymphocytes," Nature 383:787-793 (1996).
Baxter, et al., "Association Between .alpha..beta.TCR.sup.+ CD4.sup.- CD8.sup.- T-Cell Deficiency and IDDM in NOD/Lt Mice," Diabetes46:572-582 (1997).
Bendelac, et al., "Mouse CD1-Specific NK1 T Cells: Development, Specificity, and Function," Annu. Rev. Immunol. 15:535-62 (1997).
Brown, et al., ".beta.2-Microglobulin-Dependent NK1. 1.sup.+ T Cells Are Not Essential for T Helper Cell 2 Immune Responses," J. Exp. Med. 184:1295-1304 (1996).
Chen, et al., "Impaired NK1.sup.+ T Cell Development and Early IL-4 Production in CD1-Deficient Mice," Immunity 6:459-467 (1997).
Davodeau, et al., "Close Phenotypic and Functional Similarities Between Human and Murine .alpha..beta. T Cells Expressing Invariant TCR .alpha.-Chains," J. Immunol. 158:5603-5611 (1997).
Denkers, et al., "A Role for CD4.sup.+ NK1.1.sup.+ T Lymphocytes as Major Histocompatibility Complex Class II Independent Helper Cells in the Generation of CD8.sup.+ Effector Function against Intracellular Infection," J. Exp. Med. 184:131-139 (1996).
Exley, et al., "Requirements for CD1d Recognition by Human Invariant V.alpha.24.sup.+ CD4.sup.- CD8.sup.- T Cells," J. Exp. Med. 186:109-120 (1997).
Fox, et al., "IL-4 Expression at the Onset of Islet Inflammation Predicts Nondestructive Insulitis in nonobese Diabetic Mice," J. Immunol. 158:2414-2424 (1997).
Gombert, et al., "IL-7 Reverses NK1.sup.+ T Cell-Defective IL-4 Production in the Non-Obese Diabetic Mouse," Intl. Immunol. 8:1751-1758 (1996).
Kallmann, et al., "Systemic Bias of Cytokine Production Toward Cell-Mediated Immune Regulation in IDDM and Toward Humoral Immunity in Graves'Disease," Diabetes 46:237-243 (1997).
Lanier, et al., "Human NKR-P1A: A Disulfide-Linked Homodimer of the C-Type Lectin Superfamily Expressed by a Subset of NK and T Lymphocytes," J. Immunol. 153:2417-2428 (1994).
Mendiratta, et al., "CD1d1 Mutant Mice Are Deficient in Natural T Cells That Promptly Produce IL-4," Immunity 6:469-477 (1997).
Mieza, et al., "Selective Reduction of V.alpha.14.sup.+ NK T Cells Associated with Disease Development in Autoimmune-Prone Mice," J. Immunol. 156:4035-4040 (1996).
Mueller, et al., "Pancreatic Expression of Interleukin-4 Abrogates Insulitis and Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice," J. Exp. Med. 184:1093-1099 (1996).
Porcelli, et al., "Analysis of T Cell Antigen Receptor (TCR) Expression by Human Peripheral Blood CD4.sup.- 8.sup.- .alpha./.beta. T Cells Demonstrates Preferential Use of Several V.beta. Genes and an Invariant TCR .alpha. Chain," J. Exp. Med. 178:1-16 (1993).
Rapoport, et al., "Interleukin 4 Reverses T Cell Proliferative Unresponsiveness and Prevents the Onset of Diabetes in Nonobese Diabetic Mice," J. Exp. Med. 178:87-99 (1993).
Smiley, et al., "Immunoglobulin E Production in the Absence of Interleukin-4-Secreting CD1-Dependent Cells," Science 275:977-979 (1997).
Takeda, et al., "The Development of Autoimmunity in C57BL/6 lpr Mice Correlates with the Disappearance of Natural Killer Type 1-Positive Cells: Evidence for Their Suppressive Action on Bone Marrow Stem Cell Proliferation, B Cell Immunoglobulin Secretion, and Autoimmune Symptoms," J. Exp. Med. 177:155-164 (1993).
Verge, et al., "Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies," Diabetes 45:926-933 (1996).
Vicari, et al., "Mouse NK1.1.sup.+ T Cells: A New Family of T Cells," Immunology Today 17:71-76 (1996).
von Herrath, et al., "Interfeon-.gamma. Is Essential for Destruction of .beta. Cells and Development of Insulin-Dependent Diabetes Mellitus," J. Exp. Med. 185:531-539 (1997).
Hafler David A.
Kent Sally C.
Strominger Jack L.
Wilson Brian
Nolan Patrick
Sanzo Michael A.
The Brigham and Women's Hospital, Inc.
LandOfFree
Diagnostic and therapeutic methods based upon V.alpha.24J.alpha. does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diagnostic and therapeutic methods based upon V.alpha.24J.alpha., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnostic and therapeutic methods based upon V.alpha.24J.alpha. will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-270070