Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2001-07-10
2009-11-17
Yaen, Christopher H (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S005000
Reexamination Certificate
active
07618785
ABSTRACT:
A method is described for the diagnosis of an ovarian or endometrial tumor or for a prognosis, characterized in that the L1 level is determined in a patient sample, preferably via an anti L1 antibody, the presence of L1 being an indication of the presence of an ovarian or endometrial tumor or a predisposition for such a tumor. Furthermore, methods for treating of ovarian or endometrial tumors are provided.
REFERENCES:
patent: 5798445 (1998-08-01), Chu et al.
patent: 2008/0138331 (2008-06-01), Altevogt et al.
patent: 2 339 200 (2000-01-01), None
Runker AE et al. Journal of Neuroscience 23(1): 277-286, 2003.
Kadmon G et al. Developmental Immunology 6: 205-213, 1998.
Thies A et al. European Journal of Cancer 38: 1708-1716, 2002.
Katayama et al. Cell Structure and Function 22: 511-516, 1997.
DeVita VT et al. Cancer: Principles & Practice of Oncology, 5th edition, Lippincott-Raven, 1997, pp. 1478-1480 and 1502.
Bristow RE. Current Opinion in Oncology 11(5): 388, 1999.
Kadmon, Guni, et al. “The cell adhesion L1: species- and cell-type dependent multiple binding mechanisms.” Differentiation, 1997, vol. 61, pp. 143-150.
Kadmon, Guni, et al. “L1 Makes Immunological Progress by Expanding Its Relations.” Development Immunology, 1997, vol. 6, pp. 205-213.
Strobel, Thomas, et al. “β1-Integrins Partly Mediate Binding of Ovarian Cancer Cells to Peritoneal Mesothelium in Vitro.” Gynecologic Oncology, 1999, vol. 73, pp. 362-367.
Carreiras, Franck, et al. “Migration Properties of the Human Ovarian Adenocarcinoma Cell Line IGROV1: Importance of alpha-v-beta-3 Integrins and Vitronectin.” International Journal of Cancer, 1999, vol. 80, pp. 285-294.
Kadmon, Guni, et al. “The Neural Cell Adhesion Molecule N-CAM Enhances L1-dependent Cell-Cell Interactions.” Journal of Cell Biology, 1990, vol. 110, pp. 193-208.
Han, X, et al. “Tumor Lymphocytes in Patients with Advanced Ovarian Cancer: Changes during in Vitro Culture and Implications for Immunotherapy.” Gynecologic Oncology, 1997, vol. 65, pp. 391-398.
Loiudice, L., et al. “Ascitic fluid-associated lymphocytes in patients with metastatic ovarian cancer.” European Journal of Gynaecological Oncology, 1995, vol. 16, pp. 301-306.
Reid, Robert A., et al. “Variants of Human L1 Cell Adhesion Molecule Arise through Alternate Splicing of RNA.” Journal of Molecular Neuroscience, 1992, vol. 3, pp. 127-135.
Masahiro, K., et al. “Expression of Neural Cell Adhesion Molecule L1 in Human Lung Cancer Cell Lines.” Cell Structure and Function, 1997, vol. 22, pp. 511-516.
Reid, R. A., et al. “Variants of human L1 cell adhesion molecule arise through alternate splicing of RNA,” Journal of Molecular Neuroscience, (1992), vol. 3, pp. 127-135.
Kadmon, Guni, et al. “The cell adhesion molecule L1: species- and cell-type-dependent multiple binding mechanisms,” Differentiation (1997), vol. 61, pp. 143-150.
Kadmon, Guni, et al. “L1 makes immunological progress by expanding its relations,” Developmental Immunology, (1998), vo. 6, pp. 205-213.
Strobel, Thomas, et al. “β1-integrins partly mediate binding of ovarian cancer cells to peritoneal mesothelium in vitro,” Gynecologic Oncology (1999), vol. 73, pp. 362-367.
Carreiras, Franck, et al. “Migration properties of the human ovarian adenocarcinoma cell line IGORV1: importance of αvβ3 integrins and vitronectin,” International Journal of Cancer, (1999), vol. 80, pp. 285-294.
Kadmon, Guni, et al. “The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions,” Journal of Cell Biology, (1990), vol. 110, pp. 193-208.
Han, X, et al. “Tumor lymphocytes in patients with advanced ovarian cancer: changes during in vitro culture and implications for immunotherapy,” Gynecologic Oncology, (1997), vol. 65, pp. 391-398.
Loiudice, L., et al. “Ascitic fluid-associated lymphocytes in patients with metastatic ovarian cancer,” European Journal of Gynaecological Oncology, (1995), vol. 16, pp. 301-306.
Masahiro Katayama, et al. “Expression of neural cell adhesion molecule L1 in human lung cancer cell lines,” Cell Structure and Function, (1997), vol. 22, pp. 511-516.
Fogel, Mina, et al., L1 adhesion molecule (CD 171) in development and progression of human malignant melanoma , Cancer Letters, Jan. 28, 2003. pp. 237-247, vol. 189, No. 2.
Amit, A. et al., “Three Dimensional Structure of an Antigen-Antibody Complex at 2.8 angstrom Resolution”, “Science”, Aug. 15, 1986, pp. 747-753, vol. 233, No. 4756.
Panka, D. et al., “Variable Region Framework Differences Result in Decreased or Increased Affinity of Variant Anti-Digoxin Antibodies”, “Proc. Natl. Acad. of Sciences ”, May 1, 1988, pp. 3080-3084, vol. 85, No. 9.
Rudikoff, Stuart, et al., “Single Amino Acid Substitution Altering Antigen-Binding Specificity”, “Proc. Natl. Acad. Sci. USA”, Mar. 15, 1982, pp. 1979-1983, vol. 79, No. 6.
Altevogt Peter
Fogel Mina
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Recht
Hultquist Steven J.
Intellectual Property / Technology Law
Mor Research Applications Ltd.
Reynolds Kelly K.
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