Diagnostic and therapeutic methods and apparatus based on interl

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 2, C12Q 168

Patent

active

060664509

ABSTRACT:
The present invention provides methods of diagnosis of certain disease states, such as osteoporosis, that are associated with polymorphisms in an IL-6 gene, comprising determining the genotype of an IL-6 gene. The invention is also directed to methods of identifying an individual predisposed or susceptible to certain disease states, such as osteoporosis, associated with polymorphisms of an IL-6 gene, comprising determining the genotype of an IL-6 gene in the affected individual. The invention is further directed to compositions useful for determining the genotype of an IL-6 gene, to kits and diagnostic apparatuses comprising such compositions, and to methods of treatment of diseases associated with IL-6 genetic polymorphisms.

REFERENCES:
patent: 5402781 (1995-04-01), Dimarogonas
patent: 5436258 (1995-07-01), Blake et al.
patent: 5440012 (1995-08-01), Takei et al.
patent: 5441964 (1995-08-01), Bryant et al.
patent: 5593833 (1997-01-01), Morrison et al.
Bowcock, A.M., et al., "Rapid detection and sequencing of alleles in the 3' flanking region of the interleukin-6 gene," Nucl. Acids Res. 17(17):6855-6864 (1989).
Fugger, L., et al., "IL-6 Gene Polymorphism in Rheumatoid Arthritis, Pauciarticular Juvenile Rheumatoid Arthritis, Systemic Lupus Erythematosus, and in Healthy Danes," J. Immunogenet. 16:461-465 (1990).
Jacob, C.O., et al., "DNA polymorphism in cytokine genes based on length variation in simple-sequence tandem repeats," Immunogenetics 38:251-257 (1993).
Linker-Israeli, M., et al., "A Greater Variability in the 3' Flanking Region of the IL-6 Gene in Patients with Systemic Lupus Erythematosus (SLE)," Autoimmunity 23:199-209 (Mar. 1996).
Linker-Israeli, M., et al., "Skewed Allele Distribution of the IL-6 Gene Associated Minisatellite in Patients with SLE," Journal of Investigative Medicine 44(3):276a (May 1996).
Morrison, N.A., et al., "Prediction of bone density from vitamin D receptor alleles," Nature 367 :284-287 (1994).
Narayanan, S., "Laboratory Markers as an Index of Aging," Am. Clin. Lab. Sci. 26(1):50-59 (Jan.-Feb. 1996).
Radford-Smith, G., and Jewell, D.P., "Cytokines and inflammatory bowel disease," Bailliere's Clinical Gastroenterology 10(1):151-164 (Mar. 1996).
English Language Abstract of Japanese Patent Publication No. 9-12592 (Document AM1), Derwent World Patents Index, WPI Accession No. 97-128739.
English Language Abstract of Japanese Patent Publication No. 9-25293 (Document AN1), Derwent World Patents Index, WPI Accession No. 97-149801, (Jan. 1997).
English Language Abstract of Japanese Patent Publication No. 9-30977 (Document AP1), Derwent World Patents Index, WPI Accession No. 97-161424, (Jan.-Feb. 1997).
International Search Report for International Application No. PCT/GB97/01337, (1997).
Murray et al. Bone (1997) 21(1):89-92.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Diagnostic and therapeutic methods and apparatus based on interl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diagnostic and therapeutic methods and apparatus based on interl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnostic and therapeutic methods and apparatus based on interl will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1835964

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.