Diagnostic and prognostic elisa assays of serum or plasma .alpha

Details Diagnostic and prognostic elisa assays of serum or plasma .alpha Diagnostic and prognostic elisa assays of serum or plasma .alpha

1997-01-06

1998-01-27

Adams, Donald E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 723, 435 793, 435 794, 435 795, 435 18, 436501, 436531, 436813, G01N 3353

Patent

active

057121044

ABSTRACT:
Cancerous cells and HIV- and influenza virus-infected cells secrete .alpha.-N-acetylgalactosaminidase into blood stream, resulting in deglycosylation of Gc protein. This inactivates the MAF precursor activity of Gc protein, leading to immunosuppression. Thus, .alpha.-N-acetylgalactosaminidase activity in patient bloodstream can serve as diagnostic and prognostic index. Antibody-sandwich ELISA method and kits for cancer, HIV and influenza specific .alpha.-N-acetylgalactosaminidase as an antigen were developed to detect serum or plasma .alpha.-N-acetylgalactosaminidase in cancer and AIDS/HIV-infected and influenza patients and used as a diagnostic/prognostic index.

REFERENCES:
Yamamoto et al, "Deglycosylation of Serum Vitamin D3-Binding Protein Leads to Immunosuppression in Cancer Patients", Cancer Research, vol. 56, No. 12 (1996 Jun. 15), pp. 2827-2831.

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