Diagnostic and prognostic elisa assays of serum or plasma .alpha

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 71, 435 723, 435 793, 435 794, 435 795, 435 18, 436501, 436531, 436813, G01N 3353

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057121044

ABSTRACT:
Cancerous cells and HIV- and influenza virus-infected cells secrete .alpha.-N-acetylgalactosaminidase into blood stream, resulting in deglycosylation of Gc protein. This inactivates the MAF precursor activity of Gc protein, leading to immunosuppression. Thus, .alpha.-N-acetylgalactosaminidase activity in patient bloodstream can serve as diagnostic and prognostic index. Antibody-sandwich ELISA method and kits for cancer, HIV and influenza specific .alpha.-N-acetylgalactosaminidase as an antigen were developed to detect serum or plasma .alpha.-N-acetylgalactosaminidase in cancer and AIDS/HIV-infected and influenza patients and used as a diagnostic/prognostic index.

REFERENCES:
Yamamoto et al, "Deglycosylation of Serum Vitamin D3-Binding Protein Leads to Immunosuppression in Cancer Patients", Cancer Research, vol. 56, No. 12 (1996 Jun. 15), pp. 2827-2831.

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