Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1979-11-30
1981-07-14
Wyse, Thomas G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 24, 23230B, 23932, 252408, 2601125R, C12Q 138
Patent
active
042787637
ABSTRACT:
The present invention provides a diagnostic agent for the detection of proteolytic enzymes, comprising an absorbent carrier, a film layer, a powder mixture, a lyophilisate, a solution or a reagent tablet, containing at least one chromogen and an appropriate buffer substance, wherein the chromogen used is an indoxyl- and/or thioindoxyl-amino acid ester and/or peptide ester of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which can be the same or different, are hydrogen or halogen atoms, lower alkyl, lower alkoxy, aryl, aralkyl, aralkoxy, hydroxyl, carboxy, carboxy lower alkoxy, aralkoxycarbonyl, aralkyloxycarbonyl lower alkoxy, nitro or lower acylamino radicals, whereby two adjacent substituents can also represent an optionally halogenated fused benzene ring, X is a sulphur atom or an imino group optionally substituted by a lower alkyl, aryl, aralkyl or acyl radical, A is an amino acid or peptide residue and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom.
The present invention also provides new compounds of the above-given general formula and processes for the preparation thereof.
Furthermore, the present invention is concerned with the use of the compounds of the above-given general formula for the production of diagnostic agents for the detection of proteolytic enzymes.
REFERENCES:
patent: 4061625 (1977-12-01), Ekenstam et al.
patent: 4063894 (1977-12-01), Ogawa et al.
patent: 4159979 (1979-07-01), Fujino et al.
patent: 4177109 (1979-12-01), Tohyama et al.
patent: 4216142 (1980-08-01), Ali
Berger Dieter
Braun Franz
Guthlein Werner
Kuhr Manfred
Werner Wolfgang
Boehringer Mannheim GmbH
Wyse Thomas G.
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