Diagnostic agents for pancreatic exocrine function

Details Diagnostic agents for pancreatic exocrine function Diagnostic agents for pancreatic exocrine function

2007-04-24

2007-04-24

Tsang, Cecilia J. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

Reexamination Certificate

active

10482571

ABSTRACT:
A diagnostic agent for pancreatic exocrine function comprising a dipeptide represented by the following formula (I):in-line-formulae description="In-line Formulae" end="lead"?X1—R1—Y1  (I)in-line-formulae description="In-line Formulae" end="tail"?or a pharmaceutically acceptable salt thereof,wherein X1is a protecting group,R1is a phenylalanine, glutamine, valine, tyrosine, methionine, serine or threonine residue, andY1 is a13C-labeled alanine molecule optionally having a protecting group.

REFERENCES:
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B.J. Gour-Salin et al. Can. J. Chem. (1991) 69(8), pp. 1288-1297. STN/CAS Abstract only.
A. Albeck and S. Kliper. Biochem. J. (2000) 346, pp. 71-76.
“Pancreatic enzymes” by Tadashi Kohno et al., Japan J. Pharmacol., vol. 85, Sup. 1/The 74th Annual Meeting, Mar. 1, 2001, published by The Japanese Pharmacological Society, S22-3.
“Procedure for the Semisyntheses of Peptide Amides having a Glutamic or Aspartic Acid α-Amide at the C-terminal” by Henriksen, Dennis B. et al., Protein and Peptide Letters, 1998, vol. 5, No. 3, pp. 141-146.

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