Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1977-04-01
1978-06-13
Schafer, Richard E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
250303, 252316, 260122, 424 1, 424 9, A61K 2900, A61K 4300
Patent
active
040949656
ABSTRACT:
Diagnostic compositions comprising serum albumin which has been treated to remove fats and fatty acids with possible changes in molecular conformation, a reducing agent, preferably a stannous reducing agent, and a radionuclide, preferably technetium-99m, are highly useful in study and diagnosis of morphology and functions of animal tissues and organs, particularly in studying cardiovascular dynamics, placental imaging, cisternography, in determining blood and plasma volumes, in metabolism and turnover studies, in radioscintigraphic diagnosis of the lung and reticuloendothelial systems, e.g. pulmonary emboli, bronchogenic carcinoma, pneumonitis, emphysema, tuberculosis, pathology of liver and/or spleen manifest by changes in size or shape or pathology of adjacent structures or displacement of these organs, and other disorders.
For pulmonary and reticuloendothelial applications, the albumin is converted to particulate forms by denaturation under conditions which form aggregates of appropriate size.
REFERENCES:
patent: 3803299 (1974-04-01), Novel
patent: 3862299 (1975-01-01), Bruno et al.
patent: 4024233 (1977-05-01), Winchell et al.
Honda et al., Journal of Nuclear Medicine, vol. 11, No. 10, Oct. 1970, pp. 580-585.
Zolle et al., International Journal of Applied Radiation and Isotopes, vol. 21, 1970, pp. 155-167.
Layne Warren W.
Saklad Eugene L.
New England Nuclear Corporation
Nucker Christine M.
Schafer Richard E.
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