Diagnositc agent and methods for identifying HIV infected indivi

Details Diagnositc agent and methods for identifying HIV infected indivi Diagnositc agent and methods for identifying HIV infected indivi

1993-05-20

1995-11-07

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 71, 435974, 436 71, C12Q 170

Patent

active

054647401

ABSTRACT:
Disclosed herein are methods and a diagnostic agent for identifying HIV-infected individuals. The diagnostic agent, termed C-8.2, whose concentration is altered within about 1-3 days of HIV infection is used in assays not dependent on HIV antigens or antibodies. C-8.2 is present in the serum of all mammals and is a phospholipid or a mixture of related phospholipids.

REFERENCES:
patent: 4725669 (1988-02-01), Essex et al.
patent: 5028438 (1991-07-01), Chasalow et al.
patent: 5122371 (1992-06-01), Chasalow et al.
patent: 5130256 (1992-07-01), Chasalow et al.
Van Veldhoven et al., "Changes in bioactive lipoids alkylacylglycerol and ceramide, occur in HIV-infected cells", Biochem & Biophys Res Com vol. 187, No. 1 pp. 209-216 (Aug. 31, 1992).
Lynn et al: "Human Immunodeficiency Virus (HIV-1) Cytotopicity: Perturbation of the Cell Membrane & Depression of Phospholipid Synthesis", Virology 163 (1) pp. 43-51. (Mar. 1988).
Hofmann et al., "HIV Inhibits the Early Steps of Lymphocyte Activation including Initiation of Inositol Phospholipid Metabolism", J. Immunol 145(11) pp. 3699-3705 (Dec. 1990).
Hofmann et al: HIV inhibits . . . activation metabolism J. Immunol 145 (11) pp. 3699-3705. (Dec. 1, 1990).
Gallo et al., Science, 224:500-502, 1984.
DeRossi et al., Lancet, 2:278, 1988.
Blanche et al., New Eng. J. Med., 320:1643-1648, 1989.
Borkowsky et al., Lancet, 1:1169-1171, 1987.
Ward et al., New Eng. J. Med., 318:473-478, 1988.
Moss et al., AIDS, 3:55-61, 1989.
Fuchs et al., Immunology Today, 9:150-155, 1988.
Graham et al., New Eng. J. Med., 326:1037-1042, 1990.
Rakusan et al, J. of Aids, 4:116-121, 1991.
Renom et al., Res. Virol., 141:557-562, 1990.
Ades et al., The Lancet, 337:253-260, 1991.
MacDonald et al., J. of AIDS, 4:100-108, 1991.
Nkrumah et al., Cen. Afr. J. of Med., 36:116-120, 1990.
Mortimer, The Lancet, 337:286-287, 1991.
Caldwell et al., Ped. Clin. of N. Am., 38:1-35, 1991.

Affiliated with

Also associated with

Rating

Diagnositc agent and methods for identifying HIV infected indivi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diagnositc agent and methods for identifying HIV infected indivi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnositc agent and methods for identifying HIV infected indivi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-196583