Diagnosis with MCC

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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530350, 5303877, G01N 3350, G01N 3353, C07K 1630

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active

058306765

ABSTRACT:
A new human gene termed MCC is disclosed. Antibody based methods and kits are provided for assessing mutations of the MCC gene in human tissues and body samples. Gross rearrangement and point mutations in MCC are observed in human tumor cells. MCC is expressed in most normal tissues. These results suggest that MCC is a tumor suppressor.

REFERENCES:
Levy, PNAS 76:6552-6556, 1979.
Perlman, Cancer Genet Cytogenet 82:30-34, 1995.
Ashton-Rickardt, et al., High Frequency of APC Loss in Sporadic Colorectal Carcinoma Due to Breaks Clustered in 5q21-22, Oncogene,4:1169-1174, (1989).
Bodmer, et al., "Localization of the Gene for Familial Adenomatous Polyposis on Chromosome 5", Nature, 328:614-619, (1987).
Delattre, et al., "Multiple Genetic Alterations in Distal and Proximal Colorectal Cancer," The Lancet, vol. II, No. 8659, pp. 353-356 (Aug. 12, 1989).
Fearon, et al., "Identification of a Chromosome 18q Gene That Is Altered in Colorectal Cancers," Science, 247:49-56 (1990).
Fearson, et al., "A Genetic Model for Colorectal Tumorigenesis," Cell, 61:759-767 (1990).
Herrera, et al., "Brief Clinical Report: Gardner Syndrome in a Man With an Interstitial Deletion of 5q," Am. J. of Med. Genet., 25:473-476 (1986).
Monaco, et al., "Isolation of Candidate cDNAs for Portions of the Duchenne Muscular Dystrophy Gene," Nature, 323:646-650 (1986).
Nakamura, et al., "Localization of the Genetic Defect in Familial Adenomatous Polyposis Within a Small Region of Chromosome 5," Am. J. Hum. Genet., 43:638-644 (1988).
Okayama, et al., "Rapid, Nonradioactive Detection of Mutations in the Human Genome by Allele-Specific Amplification," J. Lab. Clin. Med., 114:105-113 (1989).
Rommens, et al., "Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping," Science, 245:1059-1065 (1989).
Ruano, et al., "Direct Haplotyping of Chromosomal Segments from Multiple Heterozygotes Via Allele-Specific PCR Amplification," Nucleic Acids Res., 17:8392 (1989).
Sasaki, et al., "Loss of Constitutional Heterozygosity in Colorectal Tumors from Patients with Familial Polyposis Coli and Those with Nonpolyposis Colorectal Carcinoma," Cancer Research, 49;4402-4406, 1989.
Viskochil, et al., "Deletions and a Translocation Interrupt a Cloned Gene at the Neurofibromatosis Type 1 Locus," Cell, 62:187-192 (1990).
Vogelstein, et al., "Genetic Alterations During Colorectal-Tumor Development," New Eng. J. Med., 319:525-532 (1988).
Wallace, et al., "Type 1 Neurofibromatosis Gene: Identification of a Large TRanscript Disrupted in Three NF1 Patients," Science, 249:181-186 (1990).
Wu, et al., "The Ligation Amplification Reaction (LAR)--Amplification of Specific DNA Sequences Using Sequential Rounds of Template-Dependent Ligation," Genomics, 4:560-569, 1989.
Tanaka, et al., "Suppression of Tumorigenicity in Human Colon Carcinoma Cells by Introduction of Normal Chromosome 5 or 18", Nature, 349:340-342 (1991).
Kinzler, et al., "Identification of a Gene Located at Chromosome 5q21 that is Mutated in Colorectal Cancers", Science, 251:1366-1370 (1991).
Marx, "Gene Identified for Inherited Cancer Susceptibility," Science, 253:616 (1991).
Baker et al., "Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas", Science, 244:217-221 (1989).

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