Diagnosis, prognosis, identification, and classification of...

Details Diagnosis, prognosis, identification, and classification of... Diagnosis, prognosis, identification, and classification of...

2011-07-19

2011-07-19

Zhou, Shubo (Joe) (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C435S005000, C435S006120, C702S020000, C703S011000

Reexamination Certificate

active

07983850

ABSTRACT:
Provided herein is a method for gene expression profiling multiple myeloma patients into distinct subgroups via DNA hybridization and hierarchical clustering analysis of the hybridization data where the results may further be used to identify therapeutic gene targets. Also provided is a method for controlling bone loss in an individual via pharmacological inhibitors of DKK1 protein. In addition provided herein is a method for diagnosing multiple myeloma using a 15-gene model that classifies myeloma into groups 1-7.

REFERENCES:
Gygi et al., Molecular and Cellular Biology, Mar. 1999, pp. 1720-1730.

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