Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-11-21
2006-11-21
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S006120, C435S007100, C435S007200, C435S007320, C435S007370, C435S849000, C435S965000, C435S973000, C436S506000, C436S513000, C436S517000, C436S811000
Reexamination Certificate
active
07138237
ABSTRACT:
The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence of IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
REFERENCES:
patent: 5681699 (1997-10-01), Rotter et al.
patent: 5691151 (1997-11-01), Braun et al.
patent: 5874233 (1999-02-01), Targan et al.
patent: 5916748 (1999-06-01), Targan et al.
patent: 5932429 (1999-08-01), Targan et al.
patent: 5968741 (1999-10-01), Plevy et al.
patent: 6033864 (2000-03-01), Braun et al.
patent: 6218129 (2001-04-01), Walsh et al.
patent: WO99/45955 (1999-03-01), None
patent: WO 99/49026 (1999-09-01), None
Joosens et al., Panel of Serologic Antibodies in Patients with Indeterminate Colitis, Digestive Disease Week Abstracts and Itinerary Planner (2003) vol. 2003, pp. Abstract No. M1174. (Abstract).
Zhouludev et al., American Journal of Gastroentorology, (2004) vol. 99, No. 11, pp. 2235-2241(Abstract).
Accession No. CAB07159, Hypothetical protein Rv3557c [Mycobacterium tuberculosis].
Accession No. P39897, Regulatory Protein MTRR.
Accession No. S38906, Hypothetical protein 4—Clostridium pasteurianum3.
Accession No. AAC07881, Transcriptional regulator (TetR/AcrR family) [Aquifex aeolicus].
Accession No. AF173683, Bacterium I2 unknown gene.
Blaser et al., “Patients With Active Crohn's Disease Have Elevated Serum Antibodies to Antigens of Seven Enteric Bacterial Pathogens,”Gastroenterology89:888-894 (1984).
Brandwein et al., “Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora,”J. Immunol.159:44-52 (1997).
Breeling et al., “Bacteroides vulgatusOuter Membrane Antigens Associated with Carrageenan-Induced Colitis in Guinea Pigs,”Infection and Immunity56:1754-1759 (1988).
Broekroelofs et al., “Anti-neutrophil cytoplasmic antibodies (ANCA) in sera from patients with inflammatory bowel disease (IBD). Relation to disease pattern and disease activity,”Dig. Dis. Sci39:545-549 (1994).
Cambridge et al., “Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role,”Gut33:668-674 (1992).
Cellier et al., “Mycobacterium paratuberculosisandMycobacterium aviumsubsp.SilvaticumDNA cannot be detected by PCR in Crohn's disease tissue,”Gastroenterol. Clin. Biol.22:675-678 (1998).
Chang et al., “Identification of Herpesvirus-Like DNA Sequences in AIDS-Associated Kaposi's Sarcoma,”Science266:1865-1869 (1994).
Chiba et al., “NoMycobacterium paratuberculosisdetected in intestinal tissue, including Peyer's patches and lymph follicles, of Crohn's disease,”J. Gastroenterology33:482-487 (1998).
Clarkston et al., “Role ofMycobacterium paratuberculosisCrohn's Disease,”Dis. Colon Rectum41:195-199 (1998).
Cocito et al., “Paratuberculosis,” Clinical Microbiology Reviews7(3):328-345 (1994).
Cohavy et al., “Colonic Bacteria Express an Ulcerative Colitis pANCA-Related Protein Epitope,”Infection and Immunity68:1542-1548 (2000).
Cohavy et al., “Identification of a NovelMycobacterialHistone H1 Homologue (HupB) as an Antigenic Target of pANCA Monoclonal Antibody and Serum Immunoglogublin A from Patients with Crohn's Disease,”Infection and Immunity67:6510-6517 (1999).
Cohavy et al., “Identification of Candidate Bacterial Pathogens in Ulcerative Colitis Using a Disease-specific Marker Antibody,”FASEB J.12(4):A593, Abstract 3446 (1998).
Cong et al., “CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease,”J. Exp. Med.187:855-864 (1998).
Dalwadi et al., “Identification of a novel IBD-Associated microbial agent by representational difference analysis,”Gastroenterology116(4): A696 AGA Abstracts (1999).
Davidson et al., “Antibodies to maize in patient with Crohn's disease, ulcerative colitis and coeliac disease,”Clin. Exp. Immunol.35:147-148 (1979).
Del Prete et al., “Detection ofMycobacterium paratuberculosisin stool samples of patients with inflammatory bowel disease by IS900-based PCR and colorimetric detection of amplified DNA,”J. Microbiol. Methods33:105-114 (1998).
Delcour, “Function and modulation of bacterial porins: insights from electrophysiology,”FEMS Microbiology Letters151:115-123 (1997).
Dianda et al., “T cell receptor-αβ-deficient mice fail to develop colitis in the absence of a microbial environment,”Am. J. Pathol.150:91-97 (1997).
Duchene et al., “Sequence and Transcriptional Start Site of thePseudomonas aeruginosaOuter Membrane Porin Protein F Gene,”Journal of Bacteriology170:155-162 (1988).
Duchmann et al., “Bacteria-Specific T-Cell Clones are Selective in their Reactivity Towards Different Enterobacteria orH. Pyloriand Increased in Inflammatory Bowel Disease,”Scand. J. Immunol.44:71-79 (1996).
El-Zaatari et al., “Characterization of a SpecificMycobacterium paratuberculosisRecombinant Clone Expressing 35,000-Molecular-Weight Antigen and Reactivity with Sera from Animals with Clinical and Subclinical Johne's Disease,”Journal of Clinical Microbiology35(7):1794-1799 (1997).
El-Zaatari et al., “Identification and Characterication ofMycobacterium paratuberculosisRecombinant Proteins Expressed inE. coli,” Current Microbiology29:177-184 (1994).
Elsaghier et al., “Antibodies toMycobacterium paratuberculosis-specific protein antigens in Crohn's disease,”Clin. Exp. Immunol.90:503-508 (1992).
Faille et al., “Evaluation of an enzyme immunoassay using neoglycolipids constructed fromCandida albicansoligomannosides to define the specificity of anti-mannan antibodies,”Eur. J. Microbiol. Infect. Dis.11:438-445 (1992).
Fidler et al., “Specific detection ofMycobacterium paratuberculosisDNA associated with granulomatous tissue in Crohn's disease,”Gut35:506-510 (1994).
Gui et al., “Two-year-outcomes analysis of Crohn's disease treated with rifabutin and macrolide antibiotics,”J. Antimicrob. Chemother.39:393-400 (1997).
Herfarth et al., “Interleukin 10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers,”Gut39:836-845 (1996).
Janowitz et al., “The role of the fecal stream in Crohn's disease: an historical and analytic review,”Inflamm. Bowel. Dis.4:29-39 (1998).
Knoflach et al., “Serum Antibodies to Cow's Milk Proteins in Ulcerative Colitis and Crohn's Disease,”Gastroenterology92:479-485 (1987).
Lindberg et al., “Antibody (IgG, IgA, and IgM) to baker's yeast (Saccharomyces cerevisiae), yeast mannan, gliadin, ovalbumin and betalactoglobulin in monozygotic twins with inflammatory bowel disease,”Gut33:909-913 (1992).
Lodish et al.,Molecular Cell BiologyChapter 14 (1995).
Macpherson et al., “Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria,”Gut38:365-375 (1996).
Metcalf, “Is measles infection associated with Crohn's disease?,”Brit. Med. J.316:166 (1998).
Morrissey et la., “CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. disease development is prevented by cotransfer of purified CD4+ T cells,”J. Exp. Med.178:237-244 (1993).
Moss et al., “Polymerase chain reaction detection ofMycobacterium paratuberculosisandMycobacterium aviumsubspSilvaticumin long term cultures from Crohn's disease and control tissues,”Gut33:1209-1213 (1992).
Pool et al., “Serum Antineutrophil Cytoplasmic Autoantibodies in Inflammatory Bowel Disease are Mainly Associated with Ulcerative Colitis. A Correlation Study Between Perinuclear Antineutrophil Cytoplasmic Autoantibodies and Clinical Param
Braun Jonathan
Sutton Christopher L.
Targan Stephan R.
Cedars-Sinai Medical Center
Gabel Gailene R.
Le Long V.
The Regents of the University of California
Townsend and Townsend / and Crew LLP
LandOfFree
Diagnosis, prevention and treatment of Crohn's disease using... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diagnosis, prevention and treatment of Crohn's disease using..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnosis, prevention and treatment of Crohn's disease using... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3650210