Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1980-07-18
1982-09-28
Fagelson, Anna P.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
23230B, 128 1R, 424 7, 424 94, 424180, 435 4, 435 19, 435 34, A61K 4900, C12Q 104, C12Q 144, G01N 3350
Patent
active
043518230
ABSTRACT:
A method of diagnosing the presence of tumors having .beta.-glucuronidase activity comprises administering a glucuronide which differs in color or color intensity from the aglycone thereof to a patient. The preferred glucuronide is phenolphthalein glucuronide. The urine is then collecting for a twenty four hour period and the amount of phenolphthalein glucuronides present in the urine is determined. If substantially all of the phenolphthalein glucuronide is expelled then it is apparent that the body has no tumors or bacterial infections exhibiting .beta.-glucuronidase activity. If however substantial amounts of phenolphthalein is retained, then this is an indication of the presence of tumors having .beta.-glucuronidase activity or a bacterial infection having .beta.-glucuronidase activity.
REFERENCES:
patent: 4327074 (1982-04-01), Rubin
patent: 4337760 (1982-07-01), Rubin
Goldberg, Am. J. Ob. Gyn., vol. 107, 1970, pp. 465-471.
Jones, Brit. J. Cancer, vol. 35, 1977, pp. 885-887.
Motomiya, Urological Res., vol. 3, 1975, pp. 41-48.
Fagelson Anna P.
Rubin David
Schwartz Irwin S.
Schwimmer Adolf W.
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