Diagnosis of the presence of cochlear hydrops using observed...

Surgery – Diagnostic testing – Ear or testing by auditory stimulus

Reexamination Certificate

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Reexamination Certificate

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10863559

ABSTRACT:
A procedure for diagnosing cochlear hydrops is based, in part, on an analysis of the patient's auditory brainstem response (ABR) to stimuli. The patient's ABR to a broadband click stimulus is recorded. A plurality of masked ABR's are also recorded, wherein the stimulus is masked by high-pass noise with a plurality of high-pass cut-off frequencies. The latency difference between the wave V component in the unmasked click alone response and the undermasked wave V component of a low cut-off frequency high-pass response is then calculated. If an undermasked component is not present, the normal wave V component is used. The measured latency difference is combined with another measure, such as the wave V amplitude ratio. A distribution of the combined measure is then plotted for the population and a threshold established for diagnosing cochlear hydrops. Alternatively, the joint distribution of the individual measures may be used in situations where the individual measures are known to be independent.

REFERENCES:
patent: 6080112 (2000-06-01), Don
patent: 6264616 (2001-07-01), Don
patent: 2005/0137492 (2005-06-01), Eggermont et al.
Gerull et al. Low-Frequency Masking of Brainstem Potentials. Scand Audiol 1991; 20: 227-234.
Mrowinski et al. Diagnosis of Endolymphatic Hydrops by Low-Frequency Masking. Audiol Neurootol 1996; 1: 125-134.

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