Diagnosis of spongiform or de-myelinating disease

Details Diagnosis of spongiform or de-myelinating disease Diagnosis of spongiform or de-myelinating disease

2005-02-01

2005-02-01

Swartz, Rodney P (Department: 1645)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C424S009100, C424S130100, C424S139100, C435S005000

Reexamination Certificate

active

06849418

ABSTRACT:
Disclosed are a method and a corresponding kit for detecting multiple sclerosis, Creutzfeld-Jakob disease, and/or spongiform encephalopathy in mammals. The method includes the step of testing a biological sample obtained from the mammal for IgA antibodies which bind toAcinetobacterspecies. An elevated level of such IgA antibodies is indicative of multiple sclerosis, Creutzfeld-Jakob disease, and/or spongiform encephalopathy in the mammal tested. The test kit contains an antigen specific for IgA antibodies that are reactive withAcinetobacterspecies.

REFERENCES:
patent: 5565186 (1996-10-01), Prusiner et al.
Harnet et al. (J Bacteriol 1990 172(2) pp. 956-966).*
Marchalonis et al. (Antibody as a Tool-The Applications of Immunochemistry, Chapter 2,3,13,14, John Wiley and Sons, UK 1982).

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