Diagnosis of spongiform diseases

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007320, C435S975000

Reexamination Certificate

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06949348

ABSTRACT:
A diagnostic test is provided for spongiform encephalopathy and other demyelinating conditions in mammals which comprises assaying antibodies present in the mammal which bind to an antigenic peptide which exhibits molecular mimicry of a mammalian myelin peptide, e.g. one having the sequence FSWGAEGQK. This test is useful for detecting BSE in cattle by assaying sera collected from the cattle for antibodies to a species ofAcinetobacter, AgrobacteriumorRuminococcus, or a peptide having a sequence present in the species which mimics a peptide of bovine myelin and identifying animals having a level of antibodies at least about two standard deviations above that of healthy control animals.

REFERENCES:
patent: 4038143 (1977-07-01), Juni
Eylar, E. H., et al., “Experimental Allergic Encephalomyelitis: Synthesis of Disease-Inducing Site of the Basic Protein”Science, Jun. 1970, vol. 168, No. 3936, pp 1220-1223.
Chemical Abstracts, vol. 80, No. 11, Mar. 18, 1974, Columbus, Ohio, US; abstract No. 56313, A. Wajgt.: “Assessment by immunofluorescence methods of humoral antimyelin antibody in rats with cyanide encephalopathy.” p. 68, col. 1, XP002052988, and Ann. Immunol. (Poznan), vol. 5, No. 1-2, 1973, pp. 51-58.
B.H. Toh et al.: “The 200- and 150-kDA neurofilament proteins react with 1gG autoantibodies from patients with kuru, Creutzfeldt-Jakob disease, and other neurologic diseases.” Proceedings of the National Academy of Sciences of USA., vol. 82, May 1985, Washington, US, pp. 3485-3489, XP002052986.
R.L. Sidman et al.: “Transmissible spongiform encephalopathy in the gray tremor mutant mouse.” Proceedings of the National Academy of Sciences of USA., vol. 82, Jan. 1985, Washington US, pp. 253-257, XPOO2052987.
Chemical Abstracts, vol. 109, No. 21, Nov. 21, 1988, Columbus, Ohio, US, abstract No. 187890, M. P. McKinley, et al.: “Developmental regulation of prion protein mRNA in brain.”p. 484; col. 2; and CIBA Found. Symp., vol. 135 (Novel Infect. Agents Cent. Nerv. Syst.), 1988, pp. 101-116.

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