Diagnosis of premalignant or malignant conditions of human secre

Details Diagnosis of premalignant or malignant conditions of human secre Diagnosis of premalignant or malignant conditions of human secre

1992-12-10

1995-04-04

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 15, 436 64, 436 71, 436 87, 436813, C12Q 148, G01N 33574

Patent

active

054037174

ABSTRACT:
A method for diagnostic or prognostic monitoring of premalignant or malignant conditions of human secretory epithelia, particularly colonic epithelia, by determining the extent of expression of a .beta.1-3N-acetylglucosaminyltransferase is described. Associated with the expression of a wide variety of carbohydrate antigens in adenocarcinomas is the induction of .beta.1-3N-acetylglucosaminyltransferase in epithelial cells. This enzyme is not found in normal, healthy adult colonic epithelial cells and thus indicates a novel and potentially sensitive method for screening the disease status of individuals.

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