Diagnosis of osteoarthritis by determination of asporin RNA...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S023500, C536S024310, C536S025400

Reexamination Certificate

active

07906278

ABSTRACT:
The invention relates to the identification and selection of sequences which demonstrate particular advantage in identifying individuals having osteoarthritis (OA). The invention also provides a selection of sequences particularly useful in diagnosing the degree of advancement of osteoarthritis of an individual and in the identification of novel therapeutic targets for OA. The invention further provides for the use of these sequences as a tool to diagnose disease progression and to monitor the efficacy of therapeutic regimens.

REFERENCES:
patent: 2001/0051344 (2001-12-01), Shalon et al.
patent: 0 705 842 (1996-04-01), None
patent: WO 99 32610 (1999-07-01), None
patent: WO02085285 (2002-10-01), None
Gebhard et al. Quantification of expression levels of cellular differentiation markers does not support a general shift in the cellular phenotype of osteoarthritic chondrocytes. Journal of Orthopaedic Research, vol. 21, pp. 96-101, 2003.
Kroese et al. Genetic tests and their evaluation: can we answer the key questions? Genet Med. 2004 vol. 6, No. 6, pp. 475-80, Nov.-Dec. 2004.
Lorenzo et al (Identification and characterization of asporin-a novel member of the leucine rich repeat family closely related to decorin and biglycan. The Journal of Biological Chemistry, Manuscript M010932200, pp. 1-47, Jan. 10, 2001.
McAlinden et al. Age-related changes in the synthesis and mRNA expression of decorin and aggrecan in human meniscus and articular cartilage. OsteoArthritis and Cartilage, vol. 9, pp. 33-41, Jan. 2001.
Kumar, S. et al., (2001), “Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries,”Osteoarthritis and Cartilage, 9: 641-653.
Database EMBL Online!, Van Asseldonk et al.,Homo Sapiens Alpha Gene Sequence, Database accession No. AF203815, XP002243659, Abstract, Jun. 6, 2003.
Andrews J. et al.,Gene Discovery Using Computational and Microarray Analysis of Transcription in the Drosophila Melanogaster Testis.Genome Research, vol. 10, Dec. 2000, pp. 2030-2043.
Patel I.R. et al.,TNF-Alpha Convertase Enzyme From Human Arthritis—Affected Cartilage: Isolation of cDNA by Differential Display, Expression of the Active enzyme, and Regulation of TNF—Alpha, The Journal of Immunology, 1998, 160: pp. 4570-4579.
Shukunami et al.,Expression of Cartilage-Specific Functional Matrix Chondromodulin-I mRNA in Rabbit Growth Plate Chondrocytes and Its Responsiveness to Growth Stimuli in Vitro, Biochemical and Biophysical Research Communication, vol. 249, No. 3, Aug. 28, 1998, pp. 885-890.
Alizadeh A. et al.,The Lymphochip: A Specialized CDNA Microarray for the Genomic-Scale Analysis of Gene Expression in Normal and Malignant Lymphocytes, Cold Spring Harbor Symposia on Quantitative Biology, vol. 64, No. 1, 1999, pp. 71-78.
Duggan D. J. et al.,Expression Profiling Using cDNA Microarrays, Nature Genetics, vol. 21, , Jan. 1999, pp. 10-14.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Diagnosis of osteoarthritis by determination of asporin RNA... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diagnosis of osteoarthritis by determination of asporin RNA..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnosis of osteoarthritis by determination of asporin RNA... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2781754

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.