Diagnosis of neuronal disorders and screening potential therapeu

Details Diagnosis of neuronal disorders and screening potential therapeu Diagnosis of neuronal disorders and screening potential therapeu

1988-03-22

1992-07-28

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4352402, 435948, 436548, 436811, G01N 33567

Patent

active

051340623

ABSTRACT:
A method for diagnosing a neuronal abnormality in a person includes providing living non-neural somatic cells from the person, maintaining the cells in culture under conditions in which the cells become neuronally differentiated, and detecting in the culture a metabolic indicator associated with a symptom of the neuronal abnormality. Also, a method for assaying the effectiveness of a potential therapeutic agent for treatment of a symptom of a neuronal abnormality in a patient, the symptom being associated in the neuronal abnormality with a metabolic indicator, includes treating neuronally differentiated somatic cells with the potential therapeutic agent, and detecting the metabolic indicator in the culture.

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This invention was made in the course of work supported in part by the U.S. government, which has certain rights in the invention.

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