Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2003-09-12
2008-11-18
Sullivan, Daniel M. (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023500, C536S024310
Reexamination Certificate
active
07452667
ABSTRACT:
The invention relates to the identification and selection of sequences which demonstrate particular advantage in identifying individuals having osteoarthritis (OA). The invention also provides a selection of sequences particularly useful in diagnosing the degree of advancement of osteoarthritis of an individual and in the identification of novel therapeutic targets for OA. The invention further provides for the use of these sequences as a tool to diagnose disease progression and to monitor the efficacy of therapeutic regimens.
REFERENCES:
patent: 2001/0051344 (2001-12-01), Shalon et al.
Kroese et al. Genetic tests and their evaluation: Can we answer the key questions? Genetics in Medicine. vol. 6, No. 6, pp. 475-480, 2004.
Lucentini, J. Gene Association Studies Typically Wrong. vol. 18, No. 24, p. 20 (pp. 1/4 to 4/4), 2004.
Marshall et al. Blood-based biomarkers for detecting mild osteoarthritis in the human knee. Osteoarthritis Cartilage. vol. 13, No. 10, pp. 861-871, Oct. 2005.
Uchino et al. Growth Factor Expression in the Osteophytes of the Human Femoral Head in Osteoarthritis. Clinical Orthopaedics and Related Research. vol. 377, pp. 119-125, 2000.
Liew Choong-Chin
Marshall K. Wayne
Zhang Hongwei
DeCloux Amy
Dunston Jennifer
Edwards Angell Palmer & & Dodge LLP
Genenews, Inc.
Sullivan Daniel M.
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