Diagnosis of IDDM with a panel of immunoreagents

Details Diagnosis of IDDM with a panel of immunoreagents Diagnosis of IDDM with a panel of immunoreagents

1992-05-13

1993-04-06

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 4, 436811, C12Q 100

Patent

active

052003183

ABSTRACT:
Diagnosis of insulin-dependent (Type I) diabetes mellitus (IDDM) by contacting a blood sample from a patient with an immunoreagent comprising epitopes of two or more of glutamic acid decarboxylase (GAD) and the pancreatic islet cell antigens referred to as ICA512 and ICA12. Binding of antibodies present in the blood sample with one or more of such epitopes correlates with IDDM or a potential for developing IDDM. In clinical testing, about 80 percent of sera from newly diagnosed IDDM patients react positively with at least one epitope in a GAD/ICA512 panel. Reactivity with the GAD/ICA512/ICA12 panel is between about 80 and 90 percent. The method is useful in screening patients for pre-IDDM, for distinguishing IDDM from Type II diabetes, and for monitoring therapy.

REFERENCES:
S. Baekkeskov et al., "Autoantibodies in Newly Diagnosed Diabetic Children Immunoprecipitate Human Pancreatic Islet Cell Proteins," Nature 298:167-169 (1982).
S. Baekkeskov et al., "Identification of the 64k autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase," Nature 347 151-156 (1990).
S. Baekkeskov et al., "Antibodies to a 64,000 MW Human Islet Cell Antigen Precede the Clinical Onset of Insulin-dependent Diabetes," J. Clin. Invest. 79:926-934 (1987).
M. A. Atkinson et al., "Mr. 64000 Autoantibodies (64KA) Predict Insulin Dependent Diabetes," American Diabetes Assoc. 48th Annual Meeting (1988) Abstract #391.
M. A. Atkinson et al., "64000 Mr autoantibodies as predictors of insulin-dependent diabetes," The Lancet 335:1357-1360 (1990).
Gerling, I. et al. J. of Immunol. 137:3782-3785 (1986).
Christie, M. et al, Diabetologia 31:597-602 (1988).
D. U. Rabin et al, "Cloning and Expression of IDDM-Specific Human Autoantigens" Diabetes 41:183-186 (1992).

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