Diagnosis of human glycosylation disorders

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S004000, C435S007210, C436S063000, C436S087000, C436S094000, C436S827000

Reexamination Certificate

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09857233

ABSTRACT:
This invention provides methods and kits for use in diagnosing genetically transmitted diseases that are associated with deficiencies in glycosylation of glycoconjugates such as glycoproteins, glycolipids, and proteoglycans. The methods and kits are also useful for monitoring the course of treatment of diseases that are associated with glycosylation disorders.

REFERENCES:
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Chui, Daniel, et al; “Alpha-Mannosidase-II Deficiency Results in Dyserythropoiesis And Unveils An Alternate Pathway In Oligosaccharide Biosynthesis”, Cell; 1997; pp. 167-187; vol. 90.
Hennet, Thierry, et al; “Immune Regulation By The ST6Gal Siaytransferase”;Proc. Natl. Acad. Sci.,; 1996, pp. 4604-4609; vol. 95.
Metzler, Martina, et al.; “Complex Asparagine-linked Oligosaccharides are Required For Morphogenic Events During Post-Implantation Development”;The EMBO Journal;1994, pp. 2058-2065; vol. 13.
Priatel, John J., et al.; “Isolation, Characterization And Inactivation Of The MouseMgat3Gene. The bisecting N-acetyglucosamine In Asparaigne-linked Oligosaccharides Appears Dispensible For Viability And Reproduction”; 1997, pp. 46-56; vol. 7.

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