Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-12-07
2011-10-04
Mertz, Prema (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007900, C435S007920
Reexamination Certificate
active
08030003
ABSTRACT:
Eotaxin-3, as a marker for eosinophilic esophagitis and methods of assessing, mitigating, and monitoring eosinophilic esophagitis by altering eotaxin-3 and/or CCR3 function, are disclosed.
REFERENCES:
patent: 6403782 (2002-06-01), Luster et al.
patent: 6780973 (2004-08-01), Luster et al.
patent: 0949271 (1999-10-01), None
patent: 2005/106492 (2005-11-01), None
Shinkai et al (Protein Engineering (2002) vol. 15, p. 923-929).
Blanchard, C., et al., “Inhibition of Human Interleukin-13-Induced Respiratory and Oesophageal Inflammation by Anti-Human-Interleukin-13 Antibody (CAT-354),” Clin Exp Allergy, 2005, vol. 35, pp. 1096-1103.
Elsner, Jörn, et al., “The CC Chemokine Antagonist Met-RANTES Inhibits Eosinophil Effector Functions Through the Chemokine Receptors CCR1 and CCR3,” European Journal of Immunology, 1997, vol. 27, pp. 2892-2898.
Faubion, William A., Jr., et al., “Treatment of Eosinophilic Esophagitis with Inhaled Corticosteroids,” Journal of Pediatric Gastroenterology and Nutrition, 1998, vol. 27, pp. 90-93.
Garrett, Jennifer K., et al., “Anti-Interleukin-5 (Mepolizumab) Therapy for Hypereosinophilic Syndromes,” J Allerby Clin Immunol, 2004, vol. 113, No. 1, pp. 115-119.
Hogan, S. P., et al., “Review Article: The Eosinophil as a Therapeutic Target in Gastrointestinal Disease,” Aliment Pharmacol Ther, 2004, vol. 20, pp. 1231-1240.
Kledal, Thomas N., et al., “A Broad-Spectrum Chemokine Antagonist Encoded by Kaposi's Sarcoma-Associated Herpesvirus,” Science, 1997, vol. 277, pp. 1656-1659.
Komiya, Akiko, et al., “Concerted Expression of Eotaxin-1, Eotaxin-2, and Eotaxin-3 in Human Bronchial Epithelial Cells,” Cellular Immunology, 2003, vol. 225, pp. 91-100.
Mishra, Anil, et al., “An Etiological Role for Aeroallergens and Eosinophils in Experimental Esophagitis,” The Journal of Clinical Investigation, 2001, vol. 107, pp. 83-90.
Naya, Akira, et al., “Discovery of a Novel CCR3 Selective Antagonist,” Bioorganic & Medicinal Chemistry Letters, 2001, vol. 11, pp. 1219-1223.
Naya, Akira, et al., “Structure-Activity Relationships of 2-(Benzothiazolylthio)acetamide Class of CCR3 Selective Antagonist,” Chem. Pharm. Bull., 2003, vol. 51, No. 6, pp. 697-701.
Proudfoot, Amanda E. I., et al., “Amino-terminally Modified RANTES Analogues Demonstrate Differential Effects on RANTES Receptors,” The Journal of Biological Chemistry, 1999, vol. 274, No. 45, pp. 32478-32485.
Sabroe, Ian, et al., “A Small Molecule Antagonist of Chemokine Receptors CCR1 and CCR3,” The Journal of Biological Chemistry, 2000, vol. 275, No. 34, pp. 25985-25992.
Saeki, Toshihiko, et al., “Identification of a Potent and Nonpeptidyl CCR3 Antagonist,” Biochemical and Biophysical Research Communications, 2001, vol. 281, pp. 779-782.
Teitelbaum, Jonathan E., et al., “Eosinophilic Esophagitis in Children: Immunopathological Analysis and Response to Fluticasone Propionate,” Gastroenterology, 2002, vol. 122, pp. 1216-1225.
Varnes, Jeffrey G., et al., “Discovery of N-propylurea 3-benzylpiperidines as Selective CC Chemokine Receptor-3 (CCR3) Antagonists,” Bioorganic & Medicinal Chemistry Letters, 2004, vol. 14, pp. 1645-1649.
Wacker, Dean A., et al., “CCR3 Antagonists: A Potential New Therapy for the Treatment of Asthma. Discovery and Structure-Activity Relationships,” Bioorganic & Medicinal Chemistry Letters, 2002, vol. 12, pp. 1785-1789.
Whites, John R., et al., “Identification of Potent, Selective Non-peptide CC Chemokine Receptor-3 Antagonist That Inhibits Eotaxin-, Eotaxin-2-, and Monocyte Chemotactic Protein-4-Induced Eosinophil Migration,” The Journal of Biological Chemistry, 2000, vol. 275, No. 47, pp. 36626-36631.
Zimmerman, Nives, et al., “Chemokines in Asthma: Cooperative Interaction Between Cemokines and IL-13,” J. Allergy Clin Immunol, 2003, vol. 111, No. 2, pp. 227-242.
International Search Report received in connection with PCT/US2005/044456, Dec. 7, 2006, pp. 1-7.
Children's Hospital Medical Center
Davis , Wright, Tremaine, LLP
Mertz Prema
LandOfFree
Diagnosis of eosinophilic esophagitis based on presence of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diagnosis of eosinophilic esophagitis based on presence of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnosis of eosinophilic esophagitis based on presence of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4286730