Diagnosis of cancerous or precancerous conditions in human secre

Details Diagnosis of cancerous or precancerous conditions in human secre Diagnosis of cancerous or precancerous conditions in human secre

1987-08-11

1990-11-20

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

435810, C12Q 148

Patent

active

049719050

ABSTRACT:
A method for diagnostic or prognostic monitoring of premalignant or malignant conditions of human secretory epithelia, particularly colonic epithelia, by determining the extent of expression of a .beta.1-3N-acetylglucosaminyltransferase is described. Associated with the expression of a wide variety of carbohydrate antigens in adenocarcinomas is the induction of .beta.1-3N-acetylglucosaminyltransferase in epithelial cells. This enzyme is not found in normal, healthy adult colonic epithelial cells and thus indicates a novel and potentially sensitive method for screening the disease status of individuals.

REFERENCES:
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patent: 4757003 (1988-07-01), Matsumoto et al.
Lamont et al., Jour. Natl. Cancer Inst., 54, 53-56, 1975.
Holmes et al., Jour. Biol. Chem., 262, 15649-15658, 1987.
Hakamori et al., Jour. Natl. Cancer Inst., 71, 231-251, 1983.

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