Diagnosis of cancer having clonal macrophage involvement

Details Diagnosis of cancer having clonal macrophage involvement Diagnosis of cancer having clonal macrophage involvement

1994-08-05

1996-12-03

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 435 911, 435 912, 435810, 536 231, 536 2372, 536 2433, 935 77, 935 78, C12Q 170, C12P 1934, C07H 2104, C12N 1500

Patent

active

055807151

ABSTRACT:
The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.

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