Diagnosis of blood clots using fibrin-binding proteins bound...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent

Reexamination Certificate

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Reexamination Certificate

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07465434

ABSTRACT:
This invention describes how to modify a fibrin-binding protein, such as tPA, with a contrast agent, such as iodine. This substance could then be given to a patient suspected of having a blood clot by an intravenous route, and then detected by a radiographic study at a short pre-determined time later. Appropriate therapy is started immediately as determined by the radiographic study.

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De Bruyn et al. “Visualization of thrombi in pulmonary arteries with radiolabeled, enzymatically inactivated tissue-type plasminogen activator” Circulation, 1995, 92:1320-1325.
Carroll et al. “Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing Kringle 2”, Arterioscler Thromb Vasc Biol. 2005, 25:736-741.

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