Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Patent
1995-06-23
1997-11-11
Alexander, Lyle A.
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
436 91, 436 98, 436811, G01N 3348
Patent
active
056863110
ABSTRACT:
A method for diagnosing the likelihood of autism in patients is provided which comprises first obtaining from the patient a sample of body fluid such as urine and analyzing the sample to determine the quantity therein of at least one marker compound selected from the group consisting of citramalic acid, 5-hydroxy-methyl-2-furoic acid, 3-oxo-glutaric acid, furan-2,5-dicarboxylic acid, tartaric acid, furancarbonylglycine, arabinose, dihydroxyphenylpropionic acid, carboxycitric acid and phenylcarboxylic acid; if the quantities of one or more of the compounds are abnormally high, as compared with the urine of non-autistic individuals, an ultimate diagnosis of autism is likely. The invention also pertains to a method of treating autistic patients by administration of antifungal drugs, in order to ameliorate the clinical symptoms of autism.
REFERENCES:
Shaw et al. "Increased Urinary Excretion . . . with Autistic Features", Clin. Chem. 41/8, 1094-1104(1995).
BIOSIS 87:384546.
Alexander Lyle A.
The Children's Mercy Hospital
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