Diagnosis of attention deficit hyperactivity disorder

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S004000, C436S501000, C436S503000, C436S504000

Reexamination Certificate

active

07807362

ABSTRACT:
This invention features methods and compositions useful for the treatment and diagnosis of attentional disorders including attention deficit hyperactivity disorder (ADHD). Also disclosed are methods for identifying compounds useful for such therapy.

REFERENCES:
patent: 2003/0170875 (2003-09-01), Robertson et al.
Barr et al., The Norepinephrine Transporter Gene and Attention-Deficit Hyperactivity Disorder, Am. J. Med. Genet., 114:255-259 (2002).
Bhaduri et al., Analysis of Polymorphisms in the Dopamine Beta Hydroxylase Gene: Association with Attention Deficit Hyperactivity Disorder in Indian Children, Indian Pediatrics, 42:123-129 (2005).
Bobb et al., Support for Association Between ADHD and Two Candidate Genes:NET1andDRD1, Am. J. Med. Genet., 134B:67-72 (2005).
Brookes et al., DNA Pooling Analysis of ADHD and Genes Regulating Vesicle Release of Neurotransmitters, Am. J. Med. Genet., 139B:33-37 (2005).
DeLuca et al., No Evidence of Linkage or Association Between the Norepinephrine Transporter (NET) GeneMnIIPolymorphism and Adult ADHD, Am. J. Med. Genet., 124B:38-40 (2004).
Eisenberg et al., A Haplotype Relative Risk Study of the Dopamine D4 Receptor (DRD4) Exon III Repeat Polymorphism and Attention Deficit Hyperactivity Disorder (ADHD), Am. J. Med. Genet., 96:258-261 (2000).
Funahashi et al., δ-crystallin enhancer binding protein δEF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis,Development, 119:433-446 (1993).
Hahn et al., A Mutation in the Human Norepinephrine Transporter Gene (SLC6A2) Associated with Orthostatic Intolerance Disrupts Surface Expression of Mutant and Wild-Type Transporters,J Neurosci23:4470-4478 (2003).
Hahn et al., Single Nucleotide Polymorphisms in the Human Norepinephrine Transporter Gene Affect Expression, Trafficking, Antidepressant Interaction, and Protein Kinase C Regulation,Mol Pharmacol68:457-466 (2005).
Heim, Christine and Nemeroff, Charles B., The Role of Childhood Trauma in the Neurobiology of Mood and Anxiety Disorders: Preclinical and Clinical Studies,Biol Psychiatry, 49:1023-1039 (2001).
Heinemeyer et al., Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL, Nucleic Acids Research, 26(1):362-367 (1998).
Iversen, L., Neurotransmitter transporters: fruitful targets for CNS drug discovery, Mol. Psychiatry, 5:357-362 (2000).
Kang, Yibin and Massague, Joan, Epithelial-Mesenchymal Transitions: Twist in Development and Metastasis,Cell, 118:277-279 (2004).
Kim et al., A polymorphism in the norepinephrine transorter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder, Proc. Natl. Acad. Sci. (USA), 103:19164-19169 (2006).
Klimek et al., Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression,J Neurosci17:8451-8458 (1997).
Marin, Faustino and Nieto, M. Angela, The Expression ofScratchGenes in the Developing and Adult Brain,Dev. Dyn. 235:2586-2591 (2006).
Nakakura et al., Mammalian Scratch: A neural-specific Snail family transcriptional repressor, Proc. Natl. Acad. Sci. USA 98:4010-4015, (2001).
Nieto, M. Angela, The Snail Superfamily of Zinc-Finger Transcription Factors,Nat Rev Mol Cell Biol, 3:155-166 (2002).
Savagner et al., The Zinc-Finger Protein Slug Causes Desmosome Dissociation, an Initial and Necessary Step for Growth Factor-induced Epithelial-Mesenchymal Transition, J. Cell. Biol. 137:1403-1409, (1997).
Shannon et al., Orthostatic Intolerance and Tachycardia Associated with Norepinephrine-Transporter Deficiency,N Engl J Med342, 541-9 (2000).
Solanto, M. V., Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration,Behav Brain Res, 94:127-152 (1998).
Urwin et al., Anorexia nervosa (restrictive subtype) is associated with a polymorphism in the novel norephinephrine transporter gene promoter polymorphic region,Mol Psychiatry7:652-657 (2002).
Xu et al., DNA Pooling Analysis of 21 Norepinephrine Transporter Gene SNPs With Attention Deficit Hyperactivity Disorder: No Evidence for Association, Am. J. Med. Genet., 134B:115-118 (2005).
Yang et al., Association of Norepinephrine Transporter Gene With Methylphenidate Response, J Am Acad Child Adolesc Psychiatry, 43:1154-1158, (2004).
Kim et al., A Previously undescribed intron and extensive 5′ upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene. Journal of Biological Chemistry, 274 (10), p. 6507-6518, 1999.
Kim et al., A Proximal promoter domain containing a homeodomain-binding core motif interacts with multiple transcription factors, including HoxA5 and Phox2 proteins, and critically regulates cell type-specific transcription of the human norepinephrine transporter gene. Journal of Neuroscience, 22(7): 2579-2589, 2002.
Kopal et al., Mutation screening of the human norepineprine transporter promoter. American Journal of Medical Genetics Abstracts, 122B(1): 119, 2003.
Huezo-Diaz et al., Novel mutation identification of the human norepineprine transporter promoter. American Journal of Medical Genetics Abstracts, 138B(1): 86-87, 2005.
Urwin et al., Anorexia nervosa (restrictive subtype) is associated with a polymorphism in the novel norepinephrine transporter gene promoter polymorphic region. Molecular Psychiatry, 7:652-657, 2002.
International Search Report for PCT Patent Application No. PCT/US2007/004113.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Diagnosis of attention deficit hyperactivity disorder does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diagnosis of attention deficit hyperactivity disorder, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnosis of attention deficit hyperactivity disorder will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4223413

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.