Diagnosis of Alzheimer disease

Details Diagnosis of Alzheimer disease Diagnosis of Alzheimer disease

1985-08-23

1987-10-20

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435240, C12Q 100

Patent

active

047014075

ABSTRACT:
The present invention is based on the discovery that amyotrophic lateral sclerosis (ALS), Parkinson disease and Alzheimer disease are due to lack of a disorder-specific neurotrophic hormone. Diagnosis is accomplished by assaying hormones specific for a particular neuronal network or system: the motor neurotrophic hormones from muscle in the motor neural system are used to diagnose and treat ALS, dopamine neurotrophic hormones from striatum in the nigrostriatal neural system are used to diagnose and treat parkinsonism, and cholinergic neurotrophic hormones released from the cortex and hippocampus which are specific for cholinergic neurons of the nucleus basalis and septal nucleus are used to diagnose and treat Alzheimer's disease. With tissue culture, the presence or absence of specific neurotrophic hormones can be assessed in ALS, parkinsonism, and Alzheimer disease. If there is a deficiency, extracted and purified neurotrophic hormones specific to the particular neuronal network or system can be injected in ALS and Alzheimer disease and in parkinsonism.

REFERENCES:
patent: 3989819 (1976-11-01), Brockman

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