Diagnosis and treatment of neuro-cognitive disorders associated

Details Diagnosis and treatment of neuro-cognitive disorders associated Diagnosis and treatment of neuro-cognitive disorders associated

1997-08-05

1999-09-28

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 4, 435 18, 435199, C12Q 134, C12N 922

Patent

active

059587180

ABSTRACT:
The presence of neuro-cognitive disorders associated with systemic immunological malfunction are assessed in human patients by determining the level of intracellular RNase L in a sample of the patient's peripheral blood and comparing that level to predetermined levels of RNase L in healthy individuals. Aberrant RNase L levels as compared with those in healthy individuals indicate the presence of neuro-cognitive disorders associated with systemic immunological malfunction. This procedure is useful to distinguish systemic immunological malfunction from primary psychological or neuropsychiatric disorders presenting otherwise similar clinical symptoms.

REFERENCES:
Krust et al. Virology. 120. pp. 240-246. 1982.
Ohmann et al. Journal of Interferon Research. vol. 9. pp. 159-166. 1989.
Jiang et al. Journal of Biological Chemistry. vol. 263, No. 35. pp. 19154-19158.

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