Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1989-06-26
1992-05-19
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 9, 435 792, 435965, 436506, 436518, 436536, 436811, G01N 33543, G01N 33564
Patent
active
051148447
ABSTRACT:
A 65 KD heat shock protein, proteins cross-reactive therewith, or antibodies thereto can be used for detecting in humans the existence of, a tendency to develop, or the initiation of a process leading to insulin dependent diabetes mellitus. Antibodies to hsp65 can be used to detect the hsp65 molecule in blood or urine. The hsp65 molecule of any species, or any other substance immunologically cross-reactive therewith, when administered with a tolerogenic carrier, can be used for the prevention or treatment of IDDM prior to development of clinical symptoms thereof.
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G. M. Bahr et al, Clin. Exp. Immunol., 74, 211-215, 1988.
S. Jindal et al, Molec. Cell. Biol., 9, 2279-2283, 1989.
G. Tsoufla et al, Ann. Rheum. Dis., 48, 118-123, 1989.
Cohen Irun R.
Elias Dana
Markovits Doron
Saunders David
Yeda Research and Development Co. Ltd.
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