Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Patent
1993-11-12
1996-11-26
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
4241841, 4241851, 4242481, 4242781, 530350, 530395, 530868, A61K 3904, A61K 4505, C12N 506
Patent
active
055783031
ABSTRACT:
A 65 KD heat shock protein, proteins cross-reactive therewith, antibodies thereto or T cells specific thereto can be used for detecting in humans the existence of, a tendency to develop, or the initiation of a process leading to insulin dependent diabetes mellitus. Antibodies to hsp65 can be used to detect the hsp65 molecule in blood or urine. The hsp65 molecule of any species, or any other substance immunologically cross-reactive therewith, when administered with a tolerogenic carrier, can be used for the prevention or treatment of IDDM prior to development of clinical symptoms thereof. T cells, active fragments thereof or the receptor peptide thereof can also be used for prevention or treatment of IDDM.
REFERENCES:
patent: 5114721 (1992-05-01), Cohen et al.
S. Baekkeskov et al. "Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins", Nature, 298: 167-169, 1982.
S. Baekkeskov et al., "Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase", Nature, 347: 151-156, 1990.
M. Bahr et al., "Antibody levels to mycobacteria in relation to HLA type: evidence for non-HLA-linked levels of antibody to the 65 kD heat shock protein of M.bovis in rheumatoid arthritis", Clin. Exp. Immunol., 74: 211-215, 1988.
S. Jindal et al., "Primary Structure of a Human Mitochondrial Protein Homologous to the Bacterial and Plant Chaperonins and to the 65-Kilodalton Mycobacterial Antigen", Molecular and Cellular-Biology, 9(5): 2279-2283, 1989.
G. Tsoufla et al., "Raised serum IgG and IgA antibodies to mycobacterial antigens in rheumatoid arthritis", Ann. Rheum. Dis., 48: 118-123, 1989.
J. Thole et al., "Characterization, Sequence Determination, and Immunogenicity of a 64-Kilodalton Protein of Mycobacterium bovis BCG Expressed in Escherichia coli K-12", Infection and Immunity, 55(6): 1466-1475, 1987.
F. Emmrich et al., "A Recombinant 64 Kilodalton Protein of Mycobacterium Bovis Bacillus Calmette-Guerin Specifically Stimulates Human T4 Clones Reactive to Mycobacterial Antigens," J. Exp. Med., vol. 163(4), pp. 1024-1029, Apr., 1986.
T. Ottenhoff et al., "Evidence for an HLA-DR4-Associated Immune-Response Gene for Mycobacterium Tuberculosis" The Lancet, vol. 3, No. 8502, pp. 310-313, Aug. 9, 1986.
R. Young et al., "Dissection of Mycobacterium tuberculosis antigens recombinant DNA," Proc. Natl. Acad. Sci., USA, vol. 82, pp. 2583-2587, May 1985.
J. Thole et al., "Cloning of Mycobacterium bovis BCG DNA and Expression of Antigens in Escherichia coli," Infection and Immunity, vol. 50, No. 3, pp. 800-806, Dec. 1985.
T. Shinnick et al., "The Etiologic Agents of Leprosy and Tuberculosis Share an Immunoreactive Protein Antigen with the Vaccine Strain Mycobacterium bovis BCG," Infection and Immunity, vol. 55, No. 8, pp. 1932-1935, Aug. 1987.
Proc. Natl. Acad. Sci.--USA; vol. 88, No. 8, 1991, Washington, DC, USA, pp. 3088-3091; D. Elias et al: "Vaccination against autoimmune mouse diabetes with a t-cell epitope of the human 65-kda heat shock protein".
Lancet, vol. 336, No. 2, 8 Sep. 1990, London, UK, pp. 583-585; D. B. Jones et al: "Heat-shock protein 65 as a beta cell antigen of insulin-dependent diabetes".
Cohen, Irun R., "The Self, the World and Autoimmunity", Scientific American, 256: 52-60, 1988.
Thole et al., "Characterization, Sequence Determination, and Immunogencity of a 64-Kilodalton Protein of Mycobacterium bovis BCG Expressed Escherichia coli K-12", Infection and Immunity, 55(19).
Minota et al., "Autoantibodies to the Heat-Shock Protein hsp90 in Systemic Lupus Erythematosus", J. Clin. Invest., 81: 106-109, 1988.
Res et al., "Synovial Fluid T Cell Reactivity Against 65 kD Heat Shock Protein of Mycobacteria in Early Chronic Arthritis", The Lancet, 478-480, 1988.
Vandenbark et al., "Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis", Nature, 341:541-544, 1989.
Howell et al., "Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides", Science, 246: 668-670, 1989.
Borek, F., "Immunogenicity", ed. North-Holland Publishing Co., Amsterdam, 1972; chapters 3 and 4.
D. Latchman, Nature 356:114 (1992), "No diabetes link to hsp65?".
D. Elias, et al. PNAS 88:3088-91 (Apr. 1991) "Vaccination against autoimmune mouse diabetes . . . ".
R. Maron, et al. J. Immunol. 131:2316-2322 (1983) "T lymphocyte line specific for thyroglobulin . . . ".
A. Ben-Nun, et al. Nature 292:60-1 (1981) "Vaccination against autoimmune encephalomyelitis . . . ".
D. Elias et al., "Induction and therapy of autoimmune diabetes in the nonbese disbetic (NOD/Lt) Mouse by a 65-kDa heat shock protein", PNAS, 87: 1990.
Atkinson, M. A. et al Scientific American, Jul. 1990, pp. 62-71 "What Causes Diabetes?".
Paul, W. F. (ed.) Immunology, 1989, pp. 580-583.
Van Eden et al, "Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis", Nature 331:171-173 (1988).
Rossini et al., "Immunology in Insulin-Dependent Diabetes Mellitus", Ann. Rev. Immunol. 3:289-320 (1985).
Cohen Irun R.
Elias Dana
Markovits Doron
Cunningham Thomas M.
Yeda Research and Development Co. Ltd.
LandOfFree
Diagnosis and treatment of insulin dependent diabetes mellitus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diagnosis and treatment of insulin dependent diabetes mellitus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnosis and treatment of insulin dependent diabetes mellitus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1971117