Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1995-06-06
1997-06-17
Sisson, Bradley L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 435 912, 435 9132, 435810, 53038835, 5303887, 536 235, 536 237, 536 2431, 536 2432, 536 2433, 536 253, 935 77, 935 78, C12Q 170, C12Q 168, C12P 1934, C07K 1600
Patent
active
056396007
ABSTRACT:
The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue and other cell proliferative diseased tissue. The invention also provides methods for the treatment of cell proliferative diseases induced by clonal macrophage expansion and proliferation of surrounding tissue.
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Herndier Brian
McGrath Michael S.
Shiramizu Bruce
Bozicevic Karl
Sisson Bradley L.
The Regents of the University of California
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